{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["78(5)"],"submitter":["Athan E"],"funding":["Pfizer, Inc."],"pubmed_abstract":["Background
Respiratory syncytial virus (RSV) and influenza are both typically seasonal diseases, with winter peaks in temperate climates. Coadministration of an RSV vaccine and influenza vaccine could be a benefit, requiring 1 rather than 2 visits to a healthcare provider for individuals receiving both vaccines.Methods
The primary immunogenicity objective of this phase 3, 1:1 randomized, double-blind, placebo-controlled study in healthy adults aged ≥65 years in Australia was to demonstrate noninferiority of immune responses with coadministration of the stabilized RSV prefusion F protein-based vaccine (RSVpreF) and seasonal inactivated influenza vaccine (SIIV) versus SIIV or RSVpreF administered alone, using a 1.5-fold noninferiority margin (lower bound 95% confidence interv"],"journal":["Clinical infectious diseases : an official publication of the Infectious Diseases Society of America"],"pagination":["1360-1368"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11093669"],"repository":["biostudies-literature"],"pubmed_title":["Safety and Immunogenicity of Bivalent RSVpreF Vaccine Coadministered With Seasonal Inactivated Influenza Vaccine in Older Adults."],"pmcid":["PMC11093669"],"pubmed_authors":["Gilfillan C","Ryan P","Study C3671006 Investigator Group","Cutler MW","Jiang Q","Athan E","Russo M","Quan K","Leah A","Jaques A","Baber J","Tiong F","Wark P","Mohan R","Bird P","Neville AM","Leelasena I","Scott R","Hiew V","Anderson AS","Argent C","Gurtman A","Rook C","Morbey C","Tai S","Eizenberg P","Schmoele-Thoma B","Voloshyna O","Bull S","Bloch M","De Silva G","Arya M","Nelson M","Li W","Lickliter J","McGirr A","Colquhoun D","Murdoch L","Kalinina EV","Scott RJ","Cooper D","O'Sullivan M","Deshmukh S","Swanson KA","Gruber WC","Gunner E"],"additional_accession":[]},"is_claimable":false,"name":"Safety and Immunogenicity of Bivalent RSVpreF Vaccine Coadministered With Seasonal Inactivated Influenza Vaccine in Older Adults.","description":"Background
Respiratory syncytial virus (RSV) and influenza are both typically seasonal diseases, with winter peaks in temperate climates. Coadministration of an RSV vaccine and influenza vaccine could be a benefit, requiring 1 rather than 2 visits to a healthcare provider for individuals receiving both vaccines.Methods
The primary immunogenicity objective of this phase 3, 1:1 randomized, double-blind, placebo-controlled study in healthy adults aged ≥65 years in Australia was to demonstrate noninferiority of immune responses with coadministration of the stabilized RSV prefusion F protein-based vaccine (RSVpreF) and seasonal inactivated influenza vaccine (SIIV) versus SIIV or RSVpreF administered alone, using a 1.5-fold noninferiority margin (lower bound 95% confidence interv","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T19:23:07.592Z","creation":"2026-04-19T03:14:00.962Z"},"accession":"S-EPMC11093669","cross_references":{"pubmed":["37992000"],"doi":["10.1093/cid/ciad707"]}}