biostudies-literatureHayashi SMicrosoft ResearchNIBIB NIH HHSNIDA NIH HHSNIMH NIH HHSNational Science Foundation (NSF)NINDS NIH HHSU.S. Department of Health & Human Services | National Institutes of Health (NIH)Kavli FoundationWellcome TrustU.S. Department of Health & Human Services | National Institutes of HealthNational Science Foundation809-813https://www.ebi.ac.uk/biostudies/studies/S-EPMC11093740biostudies-literatureUnknown21(5)Neuroscience is advancing standardization and tool development to support rigor and transparency. Consequently, data pipeline complexity has increased, hindering FAIR (findable, accessible, interoperable and reusable) access. brainlife.io was developed to democratize neuroimaging research. The platform provides data standardization, management, visualization and processing and automatically tracks the provenance history of thousands of data objects. Here, brainlife.io is described and evaluated for validity, reliability, reproducibility, replicability and scientific utility using four data modalities and 3,200 participants.Nature methodsbrainlife.io: a decentralized and open-source cloud platform to support neuroscience research.PMC110937402005506U01 DA041117U24 DA0411232004877U24 DA0411472232628R01 EB0308961916518U01 DA041174R01 EB02758516368931445604U01 DA041134U01 DA041156U01 DA0410931541335226486/Z/22/ZU01 DA051037U01 DA041106U01 DA041028RF1 MH133701RF1MH13370U01 DA041089U01 DA041022U01 DA041120P41 EB017183UM1 NS132207U01 DA041148U01 DA041048R01 EB029272U01 DA041025U01 DA051039U01 DA051038U01 DA051016U01 DA051018U01 DA050988U54 MH0916571734853U01 DA0509871912270U01 DA050989Pisner DPestilli FRay KLeong JKBussalb AOlivetti EPuce AHenschel RSchnyer DZuidema TRFabrega RHunt DBrown STChaumon MStewart AFreiwald WAHancock DYVeraart JMarinazzo DIacovella VWillis HGaryfallidis EVictory CHanekamp SBollmann SVinci-Booher SKoudoro SJolly JKMikellidou KGuaje JCarson JPoldrack RAKitchell LLevitas DYeh FFFischer JEke DOHeinsfeld ASSani IStewart CAHeyman SGeorge NFaskowitz JBullock DNDelogu FPort NLHayashi SNiso GMacKenzie AKurzawski JWHanson JLMcKee SStanzione DMejia AFBerto GAvesani PBridge HMcPherson BCaron BANascimento-Silva FRorden CBhatia DCraddock RCAydogan DBfalsebrainlife.io: a decentralized and open-source cloud platform to support neuroscience research.Neuroscience is advancing standardization and tool development to support rigor and transparency. Consequently, data pipeline complexity has increased, hindering FAIR (findable, accessible, interoperable and reusable) access. brainlife.io was developed to democratize neuroimaging research. The platform provides data standardization, management, visualization and processing and automatically tracks the provenance history of thousands of data objects. Here, brainlife.io is described and evaluated for validity, reliability, reproducibility, replicability and scientific utility using four data modalities and 3,200 participants.2024-01-01T00:00:00Z2024 May2025-06-01T01:39:44.932Z2025-06-01T01:39:44.932ZS-EPMC110937403860511110.1038/s41592-024-02237-2