biostudies-literatureZhong Tthe Open Fund of Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Provincethe Key Research and Development of Liangshanthe Sichuan Natural Science Foundation of China480https://www.ebi.ac.uk/biostudies/studies/S-EPMC11094944biostudies-literatureUnknown25(1)Hu sheep (HS), a breed of sheep carrying the FecB mutation gene, is known for its "year-round estrus and multiple births" and is an ideal model for studying the high fecundity mechanisms of livestock. Through analyzing and comparing the genomic selection features of Hu sheep and other sheep breeds, we identified a series of candidate genes that may play a role in Hu sheep's high fecundity mechanisms. In this study, we conducted whole-genome resequencing on six breeds and screened key mutations significantly correlated with high reproductive traits in sheep. Notably, the CC2D1B gene was selected by the fixation index (F_ST) and the cross-population composite likelihood ratio (XP-CLR) methods in HS and other five breeds. It was worth noting that the CC2D1B gene in HS was different BMC genomicsComparative whole-genome resequencing to uncover selection signatures linked to litter size in Hu Sheep and five other breeds.PMC11094944cndky-2023-022023NSFSC114421KJCX0011Zhan SZhong TZhao QZhang HHou DZhao WNiu LLi LYang SWang LfalseComparative whole-genome resequencing to uncover selection signatures linked to litter size in Hu Sheep and five other breeds.Hu sheep (HS), a breed of sheep carrying the FecB mutation gene, is known for its "year-round estrus and multiple births" and is an ideal model for studying the high fecundity mechanisms of livestock. Through analyzing and comparing the genomic selection features of Hu sheep and other sheep breeds, we identified a series of candidate genes that may play a role in Hu sheep's high fecundity mechanisms. In this study, we conducted whole-genome resequencing on six breeds and screened key mutations significantly correlated with high reproductive traits in sheep. Notably, the CC2D1B gene was selected by the fixation index (F_ST) and the cross-population composite likelihood ratio (XP-CLR) methods in HS and other five breeds. It was worth noting that the CC2D1B gene in HS was different 2024-01-01T00:00:00Z2024 May2026-07-16T07:31:27.119Z2026-07-09T10:43:29.951ZS-EPMC110949443875058210.1186/s12864-024-10396-x