{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Raj-Kumar PK"],"funding":["Henry M. Jackson Foundation","Uniformed Services University of the Health Sciences"],"pagination":["76"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11094977"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(1)"],"pubmed_abstract":["<h4>Background</h4>Breast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer death among women globally. Despite advances, there is considerable variation in clinical outcomes for patients with non-luminal A tumors, classified as difficult-to-treat breast cancers (DTBC). This study aims to delineate the proteogenomic landscape of DTBC tumors compared to luminal A (LumA) tumors.<h4>Methods</h4>We retrospectively collected a total of 117 untreated primary breast tumor specimens, focusing on DTBC subtypes. Breast tumors were processed by laser microdissection (LMD) to enrich tumor cells. DNA, RNA, and protein were simultaneously extracted from each tumor preparation, followed by whole genome sequencing, paired-end RNA sequencing, global proteomics and phosphopro"],"journal":["Breast cancer research : BCR"],"pubmed_title":["Proteogenomic characterization of difficult-to-treat breast cancer with tumor cells enriched through laser microdissection."],"pmcid":["PMC11094977"],"funding_grant_id":["HU0001-16-2-0004","W81XWH-12-2-0050"],"pubmed_authors":["Liu J","Smith RD","Lin X","Sagendorf TJ","Wang G","Liu T","Deyarmin B","Fantacone-Campbell L","Shukla AK","Kane J","Mostoller B","Moore RJ","Shriver CD","Somiari S","Raj-Kumar PK","Monroe ME","Sturtz LA","Mural RJ","Praveen-Kumar A","Melley J","Gritsenko MA","Rodland KD","McDermott JE","Hooke JA","Soon-Shiong P","Petyuk VA","Hu H","Kovatich AJ","Webb-Robertson BM","Kvecher L"],"additional_accession":[]},"is_claimable":false,"name":"Proteogenomic characterization of difficult-to-treat breast cancer with tumor cells enriched through laser microdissection.","description":"<h4>Background</h4>Breast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer death among women globally. Despite advances, there is considerable variation in clinical outcomes for patients with non-luminal A tumors, classified as difficult-to-treat breast cancers (DTBC). This study aims to delineate the proteogenomic landscape of DTBC tumors compared to luminal A (LumA) tumors.<h4>Methods</h4>We retrospectively collected a total of 117 untreated primary breast tumor specimens, focusing on DTBC subtypes. Breast tumors were processed by laser microdissection (LMD) to enrich tumor cells. DNA, RNA, and protein were simultaneously extracted from each tumor preparation, followed by whole genome sequencing, paired-end RNA sequencing, global proteomics and phosphopro","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T09:04:59.893Z","creation":"2026-04-16T03:13:02.343Z"},"accession":"S-EPMC11094977","cross_references":{"pubmed":["38745208"],"doi":["10.1186/s13058-024-01835-4"]}}