biostudies-literatureLeonenko GBrains for Dementia ResearchMedical Research CouncilAlzheimer's disease3281-3289https://www.ebi.ac.uk/biostudies/studies/S-EPMC11095482biostudies-literatureUnknown20(5)<h4>Introduction</h4>The Dementias Platform UK (DPUK) Data Portal is a data repository bringing together a wide range of cohorts. Neurodegenerative dementias are a group of diseases with highly heterogeneous pathology and an overlapping genetic component that is poorly understood. The DPUK collection of independent cohorts can facilitate research in neurodegeneration by combining their genetic and phenotypic data.<h4>Methods</h4>For genetic data processing, pipelines were generated to perform quality control analysis, genetic imputation, and polygenic risk score (PRS) derivation with six genome-wide association studies of neurodegenerative diseases. Pipelines were applied to five cohorts.<h4>Discussion</h4>The data processing pipelines, research-ready imputed genetic data, and PRS scores aAlzheimer's & dementia : the journal of the Alzheimer's AssociationDementias Platform UK: Bringing genetics into life.PMC11095482MR/S019669/1MR/L023784/2UKDRI‐3003ARUK-EXT2017A-1MR/L010305/1UKDRI-3003MR/T033371/1ARUK-PG2014-2Morgan KGhanti DEscott-Price VStevenson-Hoare JBauermeister SSimmonds EThomas AElliott PBrookes KChaturvedi NGallacher JLeonenko GWareham NfalseDementias Platform UK: Bringing genetics into life.<h4>Introduction</h4>The Dementias Platform UK (DPUK) Data Portal is a data repository bringing together a wide range of cohorts. Neurodegenerative dementias are a group of diseases with highly heterogeneous pathology and an overlapping genetic component that is poorly understood. The DPUK collection of independent cohorts can facilitate research in neurodegeneration by combining their genetic and phenotypic data.<h4>Methods</h4>For genetic data processing, pipelines were generated to perform quality control analysis, genetic imputation, and polygenic risk score (PRS) derivation with six genome-wide association studies of neurodegenerative diseases. Pipelines were applied to five cohorts.<h4>Discussion</h4>The data processing pipelines, research-ready imputed genetic data, and PRS scores a2024-01-01T00:00:00Z2024 May2026-06-02T11:35:38.444Z2026-05-27T03:12:11.247ZS-EPMC110954823850663610.1002/alz.13782