{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Huang Y"],"funding":["National Institute of Neurological Disorders and Stroke","Johns Hopkins University","Fund","NIDA NIH HHS","NIAID NIH HHS","NIMH NIH HHS","National Institutes of Health","Common","National Institute of Allergy and Infectious Diseases","NIMH","National Cancer Institute","NCI NIH HHS","NINDS NIH HHS","National Institute on Drug Abuse","NIH HHS","National Science Foundation"],"pagination":["1295-1305"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11095537"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["229(5)"],"pubmed_abstract":["Background
Brain tissue-derived extracellular vesicles (bdEVs) act locally in the central nervous system (CNS) and may indicate molecular mechanisms in human immunodeficiency virus (HIV) CNS pathology. Using brain homogenate (BH) and bdEVs from a simian immunodeficiency virus (SIV) model of HIV disease, we identified RNA networks in SIV infection and neuroinflammation.Methods
Postmortem occipital cortex samples were obtained from uninfected controls and SIV-infected subjects (acute and chronic phases with or without CNS pathology [SIV encephalitis]). bdEVs were separated and characterized per international consensus guidelines. RNAs from bdEVs and BH were sequenced and quantitative polymerase chain reaction (qPCR)-amplified to detect levels of small RNAs (sRNAs, including m"],"journal":["The Journal of infectious diseases"],"pubmed_title":["RNA Landscapes of Brain and Brain-Derived Extracellular Vesicles in Simian Immunodeficiency Virus Infection and Central Nervous System Pathology."],"pmcid":["PMC11095537"],"funding_grant_id":["DA040385","U42OD013117","UH3 CA241694","AI144997","CA241694","2244127","U42 OD013117","MH070306","DA047807","R01 AI144997","R01 NS089482","MH118164","AI094189","P01 MH070306","NS089482","MH075673","UG3 CA241694","P30 AI094189"],"pubmed_authors":["Queen S","Huang Y","Abreu CM","Zheng L","Zhu X","Turchinovich A","Witwer KW","Abdelgawad A","Batish M"],"additional_accession":[]},"is_claimable":false,"name":"RNA Landscapes of Brain and Brain-Derived Extracellular Vesicles in Simian Immunodeficiency Virus Infection and Central Nervous System Pathology.","description":"Background
Brain tissue-derived extracellular vesicles (bdEVs) act locally in the central nervous system (CNS) and may indicate molecular mechanisms in human immunodeficiency virus (HIV) CNS pathology. Using brain homogenate (BH) and bdEVs from a simian immunodeficiency virus (SIV) model of HIV disease, we identified RNA networks in SIV infection and neuroinflammation.Methods
Postmortem occipital cortex samples were obtained from uninfected controls and SIV-infected subjects (acute and chronic phases with or without CNS pathology [SIV encephalitis]). bdEVs were separated and characterized per international consensus guidelines. RNAs from bdEVs and BH were sequenced and quantitative polymerase chain reaction (qPCR)-amplified to detect levels of small RNAs (sRNAs, including m","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-05-26T14:01:13.025Z","creation":"2025-04-19T14:35:26.647Z"},"accession":"S-EPMC11095537","cross_references":{"pubmed":["38079216"],"doi":["10.1093/infdis/jiad563"]}}