{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mitchell DK"],"funding":["National Institute of Neurological Disorders and Stroke","Neurofibromatosis Therapeutic Acceleration Program","National Cancer Institute","NINDS NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["1038-1053"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11095977"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(5)"],"pubmed_abstract":["<h4>Purpose</h4>Plexiform neurofibromas (PNF) are benign peripheral nerve sheath tumors (PNST) associated with neurofibromatosis type 1 (NF1). Despite similar histologic appearance, these neoplasms exhibit diverse evolutionary trajectories, with a subset progressing to malignant peripheral nerve sheath tumor (MPNST), the leading cause of premature death in individuals with NF1. Malignant transformation of PNF often occurs through the development of atypical neurofibroma (ANF) precursor lesions characterized by distinct histopathologic features and CDKN2A copy-number loss. Although genomic studies have uncovered key driver events promoting tumor progression, the transcriptional changes preceding malignant transformation remain poorly defined.<h4>Experimental design</h4>Here we resolve gene-"],"journal":["Clinical cancer research : an official journal of the American Association for Cancer Research"],"pubmed_title":["Spatial Gene-Expression Profiling Unveils Immuno-oncogenic Programs of NF1-Associated Peripheral Nerve Sheath Tumor Progression."],"pmcid":["PMC11095977"],"funding_grant_id":["K08-NS128266-02","K08 NS128266","U54-CA196519-07","T32 GM148382","R01-NS128025-01","R01 NS128025","U54 CA196519","R01 CA282478","P30 CA082709","2004757180","R01 CA167291","T32 CA272370","U01 CA274304"],"pubmed_authors":["Burgess B","Jiang L","Hickey BE","Angus SP","Clapp DW","Smith AE","Horvai A","Bessler W","Temm C","Brewster K","Li X","Albright EA","Qian S","Fishel ML","Mang H","Rhodes SD","Mitchell DK","White EE","Sierra Potchanant EA","Pratilas CA","Lu Q"],"additional_accession":[]},"is_claimable":false,"name":"Spatial Gene-Expression Profiling Unveils Immuno-oncogenic Programs of NF1-Associated Peripheral Nerve Sheath Tumor Progression.","description":"<h4>Purpose</h4>Plexiform neurofibromas (PNF) are benign peripheral nerve sheath tumors (PNST) associated with neurofibromatosis type 1 (NF1). Despite similar histologic appearance, these neoplasms exhibit diverse evolutionary trajectories, with a subset progressing to malignant peripheral nerve sheath tumor (MPNST), the leading cause of premature death in individuals with NF1. Malignant transformation of PNF often occurs through the development of atypical neurofibroma (ANF) precursor lesions characterized by distinct histopathologic features and CDKN2A copy-number loss. Although genomic studies have uncovered key driver events promoting tumor progression, the transcriptional changes preceding malignant transformation remain poorly defined.<h4>Experimental design</h4>Here we resolve gene-","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-05-04T06:49:22.474Z","creation":"2025-04-06T13:47:18.517Z"},"accession":"S-EPMC11095977","cross_references":{"pubmed":["38127282"],"doi":["10.1158/1078-0432.CCR-23-2548","10.1158/1078-0432.ccr-23-2548"]}}