{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Campbell KL"],"funding":["NCI NIH HHS"],"pagination":["1186-1195"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11096063"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["56(6)"],"pubmed_abstract":["<h4>Purpose</h4>Detailed reporting of individually tailored exercise prescriptions (ExR x ) used in clinical trials is essential to describe feasibility, tolerability, and efficacy of the intervention and to inform translation to clinical care. This article outlines the methodology used to develop a resistance training (RT) ExR x for people with colon cancer receiving chemotherapy and reports adherence to the randomized controlled trial testing the impact of RT on relative dose intensity of chemotherapy and patient-reported toxicities.<h4>Methods</h4>Participants randomized to the exercise arm ( n = 90) were included. To promote muscle hypertrophy, the ExR x was twice-weekly, moderate to heavy loads (65%-85% one-repetition maximum), high sets (3-5), and intermediate repetitions (6-10) of five large multijoint movements with adjustable dumbbells. Attendance (achieved frequency) and adherence (achieved volume) were calculated. Group-based trajectory modeling was used to identify clusters of individuals with similar adherence patterns and compared baseline characteristics across adherence groups.<h4>Results</h4>The median attendance was 69.1%. Adherence was 60.6% but higher for those receiving 3 versus 6 months of chemotherapy (80.4 vs 47.4%; P < 0.05 ). Participants engaged in a median of 1.4 d of RT each week, lifting 62% of the one-repetition maximum load, for 3.0 sets and 7.5 repetitions per set. Three distinct adherence groups were identified: 13% \"nonstarter,\" 37% \"tapered off,\" and 50% \"consistent exercisers.\" Females were more likely to be in the nonstarter and tapered-off groups.<h4>Conclusions</h4>This article outlines suggested methods for reporting ExR x of RT in oncology clinical trials and provides insight into the tolerance of ExR x of RT during chemotherapy treatment for colon cancer. These findings aim to foster constructive dialogue and offer a premise for designing future research to elucidate the benefits of exercise during chemotherapy."],"journal":["Medicine and science in sports and exercise"],"pubmed_title":["Advances in Adherence Reporting of Resistance Training in a Clinical Trial during Adjuvant Chemotherapy for Colon Cancer."],"pmcid":["PMC11096063"],"funding_grant_id":["R01 CA206196"],"pubmed_authors":["Lee C","Li J","Vaughan M","Campbell KL","Sternfeld B","Fedric R","Meyerhardt JA","Schmitz KH","Caan BJ","Brown JC","Weltzien E","Campbell N"],"additional_accession":[]},"is_claimable":false,"name":"Advances in Adherence Reporting of Resistance Training in a Clinical Trial during Adjuvant Chemotherapy for Colon Cancer.","description":"<h4>Purpose</h4>Detailed reporting of individually tailored exercise prescriptions (ExR x ) used in clinical trials is essential to describe feasibility, tolerability, and efficacy of the intervention and to inform translation to clinical care. This article outlines the methodology used to develop a resistance training (RT) ExR x for people with colon cancer receiving chemotherapy and reports adherence to the randomized controlled trial testing the impact of RT on relative dose intensity of chemotherapy and patient-reported toxicities.<h4>Methods</h4>Participants randomized to the exercise arm ( n = 90) were included. To promote muscle hypertrophy, the ExR x was twice-weekly, moderate to heavy loads (65%-85% one-repetition maximum), high sets (3-5), and intermediate repetitions (6-10) of five large multijoint movements with adjustable dumbbells. Attendance (achieved frequency) and adherence (achieved volume) were calculated. Group-based trajectory modeling was used to identify clusters of individuals with similar adherence patterns and compared baseline characteristics across adherence groups.<h4>Results</h4>The median attendance was 69.1%. Adherence was 60.6% but higher for those receiving 3 versus 6 months of chemotherapy (80.4 vs 47.4%; P < 0.05 ). Participants engaged in a median of 1.4 d of RT each week, lifting 62% of the one-repetition maximum load, for 3.0 sets and 7.5 repetitions per set. Three distinct adherence groups were identified: 13% \"nonstarter,\" 37% \"tapered off,\" and 50% \"consistent exercisers.\" Females were more likely to be in the nonstarter and tapered-off groups.<h4>Conclusions</h4>This article outlines suggested methods for reporting ExR x of RT in oncology clinical trials and provides insight into the tolerance of ExR x of RT during chemotherapy treatment for colon cancer. These findings aim to foster constructive dialogue and offer a premise for designing future research to elucidate the benefits of exercise during chemotherapy.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-06-01T15:59:34.451Z","creation":"2026-04-08T14:03:17.131Z"},"accession":"S-EPMC11096063","cross_references":{"pubmed":["38233992"],"doi":["10.1249/mss.0000000000003395","10.1249/MSS.0000000000003395"]}}