{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Keaton JM"],"funding":["BLRD VA","NIDDK NIH HHS","NHLBI NIH HHS","NNF Center for Basic Metabolic Research","Novo Nordisk Fonden"],"pagination":["778-791"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11096100"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["56(5)"],"pubmed_abstract":["Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10<sup>-8</sup>) from the largest single-stage blood pressure (BP) genome-wide association study to date (n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing top versus bottom deciles of polygenic risk scores (PRSs) reveals clinically meaningful differences in BP (16.9 mmHg systolic BP, 95% CI, 15.5-18.2 mmHg, P = 2.22 × 10<sup>-126</sup>) and more than a sevenfold higher odds of hypertension risk (odds ratio, 7.33; 95% CI, 5.54-9.70; P = 4.13 × 10<sup>-44</sup>) in an independent dataset. Adding PRS into hypertension-prediction models increas"],"journal":["Nature genetics"],"pubmed_title":["Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits."],"pmcid":["PMC11096100"],"funding_grant_id":["NNF20OC0059313","CBMR - 008","I01 BX004821","R01 DK062370","R01 HL105756"],"pubmed_authors":["Psaty BM","Conen D","Guo X","Jukema JW","Cook JP","Melander O","Gudnason V","Attia JR","Williams A","Morrison AC","Luan J","Menni C","Chasman DI","Danesh JN","Harris SE","Deary IJ","Wright A","Warren HR","Evangelou E","Enroth S","Butterworth AS","Ani A","Oldehinkel AJ","Laan M","Keavney BD","Hayward C","Cucca F","Zheng Z","Risch L","Esko T","Nolte IM","Visscher PM","Girotto G","Raitakari OT","Spedicati B","Hui J","Caulfield MJ","Nelson CP","Watkins H","Edwards TL","Traglia M","Levy D","Zeng J","Lakatta EG","Zeggini E","Laakso M","Nalls MA","Tobin MD","Giulianini F","Concas MP","Waldenberger M","Salomaa V","Ripatti S","Loos RJF","Khaw KT","Munroe PB","Li-Gao R","Hwang SJ","Riese H","Howson JMM","Brown MJ","Wareham NJ","Ridker PM","Simonsick EM","Goel A","Rice KM","Sundstrom J","Wilson PWF","Milaneschi Y","Boehnke M","Knekt P","Scott LJ","Yengo L","Vollenweider P","Keaton JM","Kristiansson K","Teumer A","Ruggiero D","Hicks AA","Denny JC","Sever PJ","ICBP Consortium","Peters A","Palmer CNA","Rotter JI","Kolcic I","Lu Y","Johnson AD","de Geus E","Boerwinkle E","Rich SS","Wilson JF","Schmidt H","Giedraitis V","Schmidt R","Catamo E","Million Veteran Program","Marten J","Strawbridge RJ","Xie T","Gieger C","Mamasoula C","Vaez A","Cocca M","van Duijn CM","Jarvelin MR","Traylor M","Gyllensten U","Samani NJ","Hamsten A","Lifelines Cohort Study","Tuomilehto J","Kamali Z","Giri A","CHARGE consortium","Goleva SB","Poulter N","Kutalik Z","Dorr M","van der Most PJ","Polasek O","Hofer E","Liu Y","Morris AD","Sun YV","Cho K","Dominiczak AF","Siscovick D","Pramstaller PP","Hellwege JN","Spector T","Morris AP","van der Harst P","Lehtimaki T","Hottenga JJ","Kooner JS","Metspalu A","O'Donnell CJ","Strachan DP","Vitart V","Snieder H","Langenberg C","De Borst MH","Elosua R","Campbell H","Chambers JC","Campbell A","Boutin T","Newton-Cheh C","Young WJ","Trompet S"],"additional_accession":[]},"is_claimable":false,"name":"Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.","description":"Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10<sup>-8</sup>) from the largest single-stage blood pressure (BP) genome-wide association study to date (n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing top versus bottom deciles of polygenic risk scores (PRSs) reveals clinically meaningful differences in BP (16.9 mmHg systolic BP, 95% CI, 15.5-18.2 mmHg, P = 2.22 × 10<sup>-126</sup>) and more than a sevenfold higher odds of hypertension risk (odds ratio, 7.33; 95% CI, 5.54-9.70; P = 4.13 × 10<sup>-44</sup>) in an independent dataset. Adding PRS into hypertension-prediction models increas","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T06:09:52.102Z","creation":"2026-04-15T03:09:51.205Z"},"accession":"S-EPMC11096100","cross_references":{"pubmed":["38689001"],"doi":["10.1038/s41588-024-01714-w"]}}