biostudies-literatureKeaton JMBLRD VANIDDK NIH HHSNHLBI NIH HHSNNF Center for Basic Metabolic ResearchNovo Nordisk Fonden778-791https://www.ebi.ac.uk/biostudies/studies/S-EPMC11096100biostudies-literatureUnknown56(5)Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10^-8) from the largest single-stage blood pressure (BP) genome-wide association study to date (n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing top versus bottom deciles of polygenic risk scores (PRSs) reveals clinically meaningful differences in BP (16.9 mmHg systolic BP, 95% CI, 15.5-18.2 mmHg, P = 2.22 × 10^-126) and more than a sevenfold higher odds of hypertension risk (odds ratio, 7.33; 95% CI, 5.54-9.70; P = 4.13 × 10^-44) in an independent dataset. Adding PRS into hypertension-prediction models increasNature geneticsGenome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.PMC11096100NNF20OC0059313CBMR - 008I01 BX004821R01 DK062370R01 HL105756Psaty BMConen DGuo XJukema JWCook JPMelander OGudnason VAttia JRWilliams AMorrison ACLuan JMenni CChasman DIDanesh JNHarris SEDeary IJWright AWarren HREvangelou EEnroth SButterworth ASAni AOldehinkel AJLaan MKeavney BDHayward CCucca FZheng ZRisch LEsko TNolte IMVisscher PMGirotto GRaitakari OTSpedicati BHui JCaulfield MJNelson CPWatkins HEdwards TLTraglia MLevy DZeng JLakatta EGZeggini ELaakso MNalls MATobin MDGiulianini FConcas MPWaldenberger MSalomaa VRipatti SLoos RJFKhaw KTMunroe PBLi-Gao RHwang SJRiese HHowson JMMBrown MJWareham NJRidker PMSimonsick EMGoel ARice KMSundstrom JWilson PWFMilaneschi YBoehnke MKnekt PScott LJYengo LVollenweider PKeaton JMKristiansson KTeumer ARuggiero DHicks AADenny JCSever PJICBP ConsortiumPeters APalmer CNARotter JIKolcic ILu YJohnson ADde Geus EBoerwinkle ERich SSWilson JFSchmidt HGiedraitis VSchmidt RCatamo EMillion Veteran ProgramMarten JStrawbridge RJXie TGieger CMamasoula CVaez ACocca Mvan Duijn CMJarvelin MRTraylor MGyllensten USamani NJHamsten ALifelines Cohort StudyTuomilehto JKamali ZGiri ACHARGE consortiumGoleva SBPoulter NKutalik ZDorr Mvan der Most PJPolasek OHofer ELiu YMorris ADSun YVCho KDominiczak AFSiscovick DPramstaller PPHellwege JNSpector TMorris APvan der Harst PLehtimaki THottenga JJKooner JSMetspalu AO'Donnell CJStrachan DPVitart VSnieder HLangenberg CDe Borst MHElosua RCampbell HChambers JCCampbell ABoutin TNewton-Cheh CYoung WJTrompet SfalseGenome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits.Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10^-8) from the largest single-stage blood pressure (BP) genome-wide association study to date (n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing top versus bottom deciles of polygenic risk scores (PRSs) reveals clinically meaningful differences in BP (16.9 mmHg systolic BP, 95% CI, 15.5-18.2 mmHg, P = 2.22 × 10^-126) and more than a sevenfold higher odds of hypertension risk (odds ratio, 7.33; 95% CI, 5.54-9.70; P = 4.13 × 10^-44) in an independent dataset. Adding PRS into hypertension-prediction models increas2024-01-01T00:00:00Z2024 May2026-06-02T06:09:52.102Z2026-04-15T03:09:51.205ZS-EPMC110961003868900110.1038/s41588-024-01714-w