{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(3)"],"submitter":["Simmons SB"],"pubmed_abstract":["Background
Aerobic exercise (AEx) has many potential benefits; however, it is unknown whether individuals with multiple sclerosis (MS) can attain the optimal intensity and duration to harness its effects. Forced-rate exercise (FE) is a novel paradigm in which the voluntary pedaling rate during cycling is supplemented to achieve a higher exercise intensity. The aim of this pilot trial was to investigate the feasibility and initial efficacy of a 12-week FE or voluntary exercise (VE) cycling intervention for individuals with MS.Methods
Twenty-two participants with MS (Expanded Disability Severity Scale [EDSS] 2.0-6.5) were randomly assigned to FE (n = 12) or VE (n = 10), each with twice weekly 45-minute sessions at a prescribed intensity of 60% to 80% of maximum heart rate (HR"],"journal":["International journal of MS care"],"pagination":["119-124"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11096857"],"repository":["biostudies-literature"],"pubmed_title":["Intensive Aerobic Cycling Is Feasible and Elicits Improvements in Gait Velocity in Individuals With Multiple Sclerosis: A Preliminary Study."],"pmcid":["PMC11096857"],"pubmed_authors":["Streicher M","Penko AL","Li Y","Simmons SB","Love R","Bethoux F","Linder SM","Lapin B","Skolaris A","Fricker T"],"additional_accession":[]},"is_claimable":false,"name":"Intensive Aerobic Cycling Is Feasible and Elicits Improvements in Gait Velocity in Individuals With Multiple Sclerosis: A Preliminary Study.","description":"Background
Aerobic exercise (AEx) has many potential benefits; however, it is unknown whether individuals with multiple sclerosis (MS) can attain the optimal intensity and duration to harness its effects. Forced-rate exercise (FE) is a novel paradigm in which the voluntary pedaling rate during cycling is supplemented to achieve a higher exercise intensity. The aim of this pilot trial was to investigate the feasibility and initial efficacy of a 12-week FE or voluntary exercise (VE) cycling intervention for individuals with MS.Methods
Twenty-two participants with MS (Expanded Disability Severity Scale [EDSS] 2.0-6.5) were randomly assigned to FE (n = 12) or VE (n = 10), each with twice weekly 45-minute sessions at a prescribed intensity of 60% to 80% of maximum heart rate (HR","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May-Jun","modification":"2026-04-08T19:52:41.496Z","creation":"2026-04-08T14:33:47.393Z"},"accession":"S-EPMC11096857","cross_references":{"pubmed":["38765298"],"doi":["10.7224/1537-2073.2023-042"]}}