{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Frantzi N"],"funding":["Bundesministerium für Bildung und Forschung","Universitätsklinikum Freiburg","Federal Ministry of Education and Research"],"pagination":["207"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11097413"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(1)"],"pubmed_abstract":["Background
The evidence regarding effects of statins on exacerbation risk in COPD remains controversial. Previous studies often excluded patients with cardiovascular comorbidities despite their high prevalence in COPD and role for exacerbations. Based on the cardioprotective properties of statins, we hypothesised that statins may reduce the risk of exacerbations especially in patients with cardiovascular comorbidities.Methods
One thousand eight hundred eighty seven patients of the German COPD cohort COSYCONET (COPD and Systemic Consequences Comorbidities Network) of GOLD grades 1-4 (37.8% female, mean age 64.78 ± 8.3) were examined at baseline and over a period of 4.5 years for the occurrence of at least one exacerbation or severe exacerbation per year in cross-sectional an"],"journal":["Respiratory research"],"pubmed_title":["Statins did not reduce the frequency of exacerbations in individuals with COPD and cardiovascular comorbidities in the COSYCONET cohort."],"pmcid":["PMC11097413"],"funding_grant_id":["number 01 GI 0881"],"pubmed_authors":["Rohde G","Kropf-Sanchen C","Wirtz H","Grohe C","Seiler F","Schmeck B","Frantzi N","Kronsbein J","Michels-Zetsche JD","Herth F","Watz H","German COSYCONET Cohort","Welte T","Taube C","Herr C","Jorres RA","Henke M","Soriano D","Ficker H","Ewert R","Stolz D","Seeger W","Bahmer T","Waschki B","Kahnert K","Timmermann H","Omlor A","Bewig B","Sohler S","Kauczor HU","Randerath J","Biertz F","Studnicka M","Trinkmann F","Vogelmeier CF","Andreas S","Nguyen XP","Held M","Fahndrich S","Herzmann C","Pfeifer M","Bals R","Koczulla R","Kirsten AM","Alter P","Behr J","Trudzinski FC","Moneke I","Stubbe B","Eichenlaub M"],"additional_accession":[]},"is_claimable":false,"name":"Statins did not reduce the frequency of exacerbations in individuals with COPD and cardiovascular comorbidities in the COSYCONET cohort.","description":"Background
The evidence regarding effects of statins on exacerbation risk in COPD remains controversial. Previous studies often excluded patients with cardiovascular comorbidities despite their high prevalence in COPD and role for exacerbations. Based on the cardioprotective properties of statins, we hypothesised that statins may reduce the risk of exacerbations especially in patients with cardiovascular comorbidities.Methods
One thousand eight hundred eighty seven patients of the German COPD cohort COSYCONET (COPD and Systemic Consequences Comorbidities Network) of GOLD grades 1-4 (37.8% female, mean age 64.78 ± 8.3) were examined at baseline and over a period of 4.5 years for the occurrence of at least one exacerbation or severe exacerbation per year in cross-sectional an","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T06:10:34.269Z","creation":"2026-04-15T03:09:51.048Z"},"accession":"S-EPMC11097413","cross_references":{"pubmed":["38750572"],"doi":["10.1186/s12931-024-02822-1"]}}