{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Le Pennec R"],"funding":["Brest University Hospital","International Network of Venous Thromboembolism Research Networks"],"pagination":["e075712"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11097801"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(5)"],"pubmed_abstract":["<h4>Introduction</h4>Pulmonary embolism (PE) is a challenge to diagnose and when missed, exposes patients to potentially fatal recurrent events. Beyond CT pulmonary angiography (CTPA) and planar ventilation/perfusion (V/Q) scan, single photon emission CT (SPECT) V/Q emerged a new diagnostic modality of scintigraphic acquisition that has been reported to improve diagnostic performances. To date, no management outcome study or randomised trial evaluated an algorithm based on SPECT V/Q for PE diagnosis. We present the design of a randomised multicentre, international management study comparing SPECT V/Q with validated strategies.<h4>Material and methods</h4>We will include a total of 3672 patients with suspected PE requiring chest imaging, randomised into three different groups, each using a "],"journal":["BMJ open"],"pubmed_title":["Comparison of three diagnostic strategies for suspicion of pulmonary embolism: planar ventilation-perfusion scan (V/Q), CT pulmonary angiography (CTPA) and single photon emission CT ventilation-perfusion scan (SPECT V/Q): a protocol of a randomised controlled trial."],"pmcid":["PMC11097801"],"funding_grant_id":["N/A"],"pubmed_authors":["Le Roux PY","Salaun PY","Robin P","Righini M","Le Gal G","Le Pennec R","Couturaud F"],"additional_accession":[]},"is_claimable":false,"name":"Comparison of three diagnostic strategies for suspicion of pulmonary embolism: planar ventilation-perfusion scan (V/Q), CT pulmonary angiography (CTPA) and single photon emission CT ventilation-perfusion scan (SPECT V/Q): a protocol of a randomised controlled trial.","description":"<h4>Introduction</h4>Pulmonary embolism (PE) is a challenge to diagnose and when missed, exposes patients to potentially fatal recurrent events. Beyond CT pulmonary angiography (CTPA) and planar ventilation/perfusion (V/Q) scan, single photon emission CT (SPECT) V/Q emerged a new diagnostic modality of scintigraphic acquisition that has been reported to improve diagnostic performances. To date, no management outcome study or randomised trial evaluated an algorithm based on SPECT V/Q for PE diagnosis. We present the design of a randomised multicentre, international management study comparing SPECT V/Q with validated strategies.<h4>Material and methods</h4>We will include a total of 3672 patients with suspected PE requiring chest imaging, randomised into three different groups, each using a ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T11:25:26.085Z","creation":"2026-05-27T03:07:44.974Z"},"accession":"S-EPMC11097801","cross_references":{"pubmed":["38754880"],"doi":["10.1136/bmjopen-2023-075712"]}}