biostudies-literatureMadi MMinistry of EducationImam Abdulrahman Bin Faisal University, College of Dentistrye17374https://www.ebi.ac.uk/biostudies/studies/S-EPMC11097963biostudies-literatureUnknown12<h4>Background</h4>An increased level of interleukin-17A and interleukin-18 in the serum and intestinal mucosa of celiac disease patients reflecting the severity of villous atrophy and inflammation was documented. Thus, the objective of this study was to evaluate the concentrations of salivary-17A, interleukin-1 beta, and interleukin-18 in patients with celiac disease who are on a gluten-free diet, both with and without periodontitis, and to compare these levels with those in healthy individuals.<h4>Methods</h4>The study involved 23 participants with serologically confirmed celiac disease (CD) and 23 control subjects. The CD patients had been following a gluten-free diet (GFD) for a minimum of 1 year and had no other autoimmune disorders. The research involved collecting demographic data, PeerJSalivary interleukin-17A and interleukin-18 levels in patients with celiac disease and periodontitis.PMC11097963IF-2020-006-DentAlhafid IAAbdelsalam MZakaria OAlMuhaish LMadi MAlamri TAAlzahrani IMAlasseri IAAlQuorain AAElakel AAlhashmi MTAlam AHAlqahtani MFarooqi FAlGhamdi MfalseSalivary interleukin-17A and interleukin-18 levels in patients with celiac disease and periodontitis.<h4>Background</h4>An increased level of interleukin-17A and interleukin-18 in the serum and intestinal mucosa of celiac disease patients reflecting the severity of villous atrophy and inflammation was documented. Thus, the objective of this study was to evaluate the concentrations of salivary-17A, interleukin-1 beta, and interleukin-18 in patients with celiac disease who are on a gluten-free diet, both with and without periodontitis, and to compare these levels with those in healthy individuals.<h4>Methods</h4>The study involved 23 participants with serologically confirmed celiac disease (CD) and 23 control subjects. The CD patients had been following a gluten-free diet (GFD) for a minimum of 1 year and had no other autoimmune disorders. The research involved collecting demographic data, 2024-01-01T00:00:00Z20242026-06-01T17:30:51.841Z2026-04-08T14:19:50.069ZS-EPMC110979633875644510.7717/peerj.17374