{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Amorim Sacramento L"],"funding":["NIAID NIH HHS","National Institutes of Health"],"pagination":["e1012211"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11098486"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(5)"],"pubmed_abstract":["Cytolytic CD8+ T cells mediate immunopathology in cutaneous leishmaniasis without controlling parasites. Here, we identify factors involved in CD8+ T cell migration to the lesion that could be targeted to ameliorate disease severity. CCR5 was the most highly expressed chemokine receptor in patient lesions, and the high expression of CCL3 and CCL4, CCR5 ligands, was associated with delayed healing of lesions. To test the requirement for CCR5, Leishmania-infected Rag1-/- mice were reconstituted with CCR5-/- CD8+ T cells. We found that these mice developed smaller lesions accompanied by a reduction in CD8+ T cell numbers compared to controls. We confirmed these findings by showing that the inhibition of CCR5 with maraviroc, a selective inhibitor of CCR5, reduced lesion development without aff"],"journal":["PLoS pathogens"],"pubmed_title":["CCR5 promotes the migration of pathological CD8+ T cells to the leishmanial lesions."],"pmcid":["PMC11098486"],"funding_grant_id":["RO1-AI-136862","P50-AI-030639","R01 AI150606","RO1-AI-143790","R01-AI-162711","RO1-AI-149456","R01 AI136862","R01 AI162711","R01 AI149456","R01 AI143790","RO1-AI-150606","P50 AI030639"],"pubmed_authors":["Amorim Sacramento L","Farias Amorim C","M Carvalho E","Scott P","G Lombana C","Beiting D","P Carvalho L","Novais F"],"additional_accession":[]},"is_claimable":false,"name":"CCR5 promotes the migration of pathological CD8+ T cells to the leishmanial lesions.","description":"Cytolytic CD8+ T cells mediate immunopathology in cutaneous leishmaniasis without controlling parasites. Here, we identify factors involved in CD8+ T cell migration to the lesion that could be targeted to ameliorate disease severity. CCR5 was the most highly expressed chemokine receptor in patient lesions, and the high expression of CCL3 and CCL4, CCR5 ligands, was associated with delayed healing of lesions. To test the requirement for CCR5, Leishmania-infected Rag1-/- mice were reconstituted with CCR5-/- CD8+ T cells. We found that these mice developed smaller lesions accompanied by a reduction in CD8+ T cell numbers compared to controls. We confirmed these findings by showing that the inhibition of CCR5 with maraviroc, a selective inhibitor of CCR5, reduced lesion development without aff","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-02T21:23:41.3Z","creation":"2026-04-20T03:14:22.24Z"},"accession":"S-EPMC11098486","cross_references":{"pubmed":["38709823"],"doi":["10.1371/journal.ppat.1012211"]}}