{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cobo Marcos M"],"funding":["Instituto de Salud Carlos III"],"pagination":["1767-1776"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11098644"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(3)"],"pubmed_abstract":["Aims
Hypertonic saline solution (HSS) plus intravenous (IV) loop diuretic appears to enhance the diuretic response in patients hospitalized for heart failure (HF). The efficacy and safety of this therapy in the ambulatory setting have not been evaluated. We aimed to describe the design and baseline characteristics of the SALT-HF trial participants.Methods and results
'Efficacy of Saline Hypertonic Therapy in Ambulatory Patients with HF' (SALT-HF) trial was a multicenter, double-blinded, and randomized study involving ambulatory patients who experienced worsening heart failure (WHF) without criteria for hospitalization. Enrolled patients had to present at least two signs of volume overload, use ≥ 80 mg of oral furosemide daily, and have elevated natriuretic peptides. Patient"],"journal":["ESC heart failure"],"pubmed_title":["Design and baseline characteristics of SALT-HF trial: hypertonic saline therapy in ambulatory heart failure."],"pmcid":["PMC11098644"],"funding_grant_id":["PI20/00689"],"pubmed_authors":["Comin-Colet J","Goirigolzarri-Artaza J","Del Prado Diaz S","Montero Hernandez E","Nunez J","Rubio Gracia J","Barrios E","Cobo Marcos M","Zegri I","Morales-Rull JL","Sanchez-Marteles M","de Juan Baguda J","Garcia-Pinilla JM","Llacer P","Ortiz Cortes C","Diez-Villanueva P","de la Espriella R","Jimenez-Marrero S"],"additional_accession":[]},"is_claimable":false,"name":"Design and baseline characteristics of SALT-HF trial: hypertonic saline therapy in ambulatory heart failure.","description":"Aims
Hypertonic saline solution (HSS) plus intravenous (IV) loop diuretic appears to enhance the diuretic response in patients hospitalized for heart failure (HF). The efficacy and safety of this therapy in the ambulatory setting have not been evaluated. We aimed to describe the design and baseline characteristics of the SALT-HF trial participants.Methods and results
'Efficacy of Saline Hypertonic Therapy in Ambulatory Patients with HF' (SALT-HF) trial was a multicenter, double-blinded, and randomized study involving ambulatory patients who experienced worsening heart failure (WHF) without criteria for hospitalization. Enrolled patients had to present at least two signs of volume overload, use ≥ 80 mg of oral furosemide daily, and have elevated natriuretic peptides. Patient","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-06-02T11:32:38.962Z","creation":"2026-05-27T03:08:17.414Z"},"accession":"S-EPMC11098644","cross_references":{"pubmed":["38380837"],"doi":["10.1002/ehf2.14720"]}}