{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hillary RF"],"funding":["British Heart Foundation","Medical Research Council","Diabetes UK","Alzheimer's Society","Biotechnology and Biological Sciences Research Council"],"pagination":["100544"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11099341"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["4(5)"],"pubmed_abstract":["Chronic inflammation is a hallmark of age-related disease states. The effectiveness of inflammatory proteins including C-reactive protein (CRP) in assessing long-term inflammation is hindered by their phasic nature. DNA methylation (DNAm) signatures of CRP may act as more reliable markers of chronic inflammation. We show that inter-individual differences in DNAm capture 50% of the variance in circulating CRP (N = 17,936, Generation Scotland). We develop a series of DNAm predictors of CRP using state-of-the-art algorithms. An elastic-net-regression-based predictor outperformed competing methods and explained 18% of phenotypic variance in the Lothian Birth Cohort of 1936 (LBC1936) cohort, doubling that of existing DNAm predictors. DNAm predictors performed comparably in four additional test cohorts (Avon Longitudinal Study of Parents and Children, Health for Life in Singapore, Southall and Brent Revisited, and LBC1921), including for individuals of diverse genetic ancestry and different age groups. The best-performing predictor surpassed assay-measured CRP and a genetic score in its associations with 26 health outcomes. Our findings forge new avenues for assessing chronic low-grade inflammation in diverse populations."],"journal":["Cell genomics"],"pubmed_title":["Blood-based epigenome-wide analyses of chronic low-grade inflammation across diverse population cohorts."],"pmcid":["PMC11099341"],"funding_grant_id":["PG/08/103/26133","BB/I025263/1","HDR-23012","13/0004774","BB/I025751/1","010"],"pubmed_authors":["Huang F","Elliott HR","McCartney DL","Corley J","Walker RM","Relton CL","Sattar N","Suderman M","Hillary RF","Ng HK","Sudlow C","Loh M","Yousefi PD","Chambers JC","Direk K","Cox SR","Evans KL","Marioni RE","McIntosh AM","Campbell A","Welsh P","Hayward C"],"additional_accession":[]},"is_claimable":false,"name":"Blood-based epigenome-wide analyses of chronic low-grade inflammation across diverse population cohorts.","description":"Chronic inflammation is a hallmark of age-related disease states. The effectiveness of inflammatory proteins including C-reactive protein (CRP) in assessing long-term inflammation is hindered by their phasic nature. DNA methylation (DNAm) signatures of CRP may act as more reliable markers of chronic inflammation. We show that inter-individual differences in DNAm capture 50% of the variance in circulating CRP (N = 17,936, Generation Scotland). We develop a series of DNAm predictors of CRP using state-of-the-art algorithms. An elastic-net-regression-based predictor outperformed competing methods and explained 18% of phenotypic variance in the Lothian Birth Cohort of 1936 (LBC1936) cohort, doubling that of existing DNAm predictors. DNAm predictors performed comparably in four additional test cohorts (Avon Longitudinal Study of Parents and Children, Health for Life in Singapore, Southall and Brent Revisited, and LBC1921), including for individuals of diverse genetic ancestry and different age groups. The best-performing predictor surpassed assay-measured CRP and a genetic score in its associations with 26 health outcomes. Our findings forge new avenues for assessing chronic low-grade inflammation in diverse populations.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-05-27T12:15:21.661Z","creation":"2026-05-27T03:07:35.699Z"},"accession":"S-EPMC11099341","cross_references":{"pubmed":["38692281"],"doi":["10.1016/j.xgen.2024.100544"]}}