biostudies-literatureCheng KNIBIB NIH HHSNational Institute of Biomedical Imaging and Bioengineering3419-3423https://www.ebi.ac.uk/biostudies/studies/S-EPMC11099534biostudies-literatureUnknown26(16)We present a photo- and Cu-mediated ¹¹C cyanation of bench-stable (hetero)aryl thianthrenium salts via an aryl radical addition pathway. The thianthrenium substrates can be readily accessed via C-H functionalization, and the radiocyanation protocol proceeds under mild conditions (<50 °C, 5 min) and can be automated using open-source, readily accessible augmentations to existing radiochemistry equipment.Organic lettersPhoto- and Cu-Mediated ¹¹C Cyanation of (Hetero)Aryl Thianthrenium Salts.PMC11099534K99 EB031564R01 EB021155R01EB021155K99EB031564Scott PJHShao XWright JSSanford MSCheng KBowden GDWebb EWfalsePhoto- and Cu-Mediated ¹¹C Cyanation of (Hetero)Aryl Thianthrenium Salts.We present a photo- and Cu-mediated ¹¹C cyanation of bench-stable (hetero)aryl thianthrenium salts via an aryl radical addition pathway. The thianthrenium substrates can be readily accessed via C-H functionalization, and the radiocyanation protocol proceeds under mild conditions (<50 °C, 5 min) and can be automated using open-source, readily accessible augmentations to existing radiochemistry equipment.2024-01-01T00:00:00Z2024 Apr2025-07-01T03:05:47.039Z2025-07-01T03:05:47.039ZS-EPMC110995343863057310.1021/acs.orglett.4c00929