biostudies-literatureTsang RSData and Connectivity National Core Study, led by Health Data Research UK in partnership with the Office for National Statistics and funded by UK Research and InnovationMedical Research Council134-148https://www.ebi.ac.uk/biostudies/studies/S-EPMC11100448biostudies-literatureUnknown117(4)<h4>Objectives</h4>To estimate the incidence of adverse events of interest (AEIs) after receiving their first and second doses of coronavirus disease 2019 (COVID-19) vaccinations, and to report the safety profile differences between the different COVID-19 vaccines.<h4>Design</h4>We used a self-controlled case series design to estimate the relative incidence (RI) of AEIs reported to the Oxford-Royal College of General Practitioners national sentinel network. We compared the AEIs that occurred seven days before and after receiving the COVID-19 vaccinations to background levels between 1 October 2020 and 12 September 2021.<h4>Setting</h4>England, UK.<h4>Participants</h4>Individuals experiencing AEIs after receiving first and second doses of COVID-19 vaccines.<h4>Main outcome measures</h4>AEIsJournal of the Royal Society of MedicineAdverse events after first and second doses of COVID-19 vaccination in England: a national vaccine surveillance platform self-controlled case series study.PMC11100448HDRUK2021.0056MC_PC_20058MC_PC_20029O'Reilly DAgrawal UChuter ARichard Hobbs FDJoy MWilliams JVictor WAnand SNBeggs JSheikh AHowsam GKar DLusignan SAkbari ARobertson CHinton WTsang RSMayor NOwen RKBradley DTByford RMurphy SfalseAdverse events after first and second doses of COVID-19 vaccination in England: a national vaccine surveillance platform self-controlled case series study.<h4>Objectives</h4>To estimate the incidence of adverse events of interest (AEIs) after receiving their first and second doses of coronavirus disease 2019 (COVID-19) vaccinations, and to report the safety profile differences between the different COVID-19 vaccines.<h4>Design</h4>We used a self-controlled case series design to estimate the relative incidence (RI) of AEIs reported to the Oxford-Royal College of General Practitioners national sentinel network. We compared the AEIs that occurred seven days before and after receiving the COVID-19 vaccinations to background levels between 1 October 2020 and 12 September 2021.<h4>Setting</h4>England, UK.<h4>Participants</h4>Individuals experiencing AEIs after receiving first and second doses of COVID-19 vaccines.<h4>Main outcome measures</h4>AEIs2024-01-01T00:00:00Z2024 Apr2026-04-12T15:30:34.516Z2026-04-07T13:18:01.449ZS-EPMC111004483792153810.1177/01410768231205430