biostudies-literatureUnknownBerndsen ZTBLRD VANIAID NIH HHSEnterotoxigenic <i>Escherichia coli</i> (ETEC) cause hundreds of millions of cases of infectious diarrhea annually, predominantly in children from low-middle income regions. Notably, in children, as well as human volunteers challenged with ETEC, diarrheal severity is significantly increased severity in blood group A (bgA) individuals. EtpA, is a secreted glycoprotein adhesin that functions as a blood group A lectin to promote critical interactions between ETEC and blood group A glycans on intestinal epithelia for effective bacterial adhesion and toxin delivery. EtpA is highly immunogenic resulting in robust antibody responses following natural infection and experimental challenge of human volunteers with ETEC. To understand how EtpA directs ETEC-blood group A interactions and stimulates adbioRxiv : the preprint server for biology2024.05.08.593125https://www.ebi.ac.uk/biostudies/studies/S-EPMC11100705biostudies-literatureRepeat modules and N-linked glycans define structure and antigenicity of a critical enterotoxigenic <i>E. coli adhesin</i>.PMC11100705T32 AI007172R01 AI089894R01 AI126887I01 BX001469Poly FLaird RMVickers TTurner JSThapa MEllebedy AHSheikh ADiedrich JKBaboo SKumar PKhatoom NTorres JLFleckenstein JMSchmitz AMartinez-Bartolome SGarrett PTYates JRHamrick MBerndsen ZTAkhtar MPorter CKCopps JWard ABfalseRepeat modules and N-linked glycans define structure and antigenicity of a critical enterotoxigenic <i>E. coli adhesin</i>.Enterotoxigenic <i>Escherichia coli</i> (ETEC) cause hundreds of millions of cases of infectious diarrhea annually, predominantly in children from low-middle income regions. Notably, in children, as well as human volunteers challenged with ETEC, diarrheal severity is significantly increased severity in blood group A (bgA) individuals. EtpA, is a secreted glycoprotein adhesin that functions as a blood group A lectin to promote critical interactions between ETEC and blood group A glycans on intestinal epithelia for effective bacterial adhesion and toxin delivery. EtpA is highly immunogenic resulting in robust antibody responses following natural infection and experimental challenge of human volunteers with ETEC. To understand how EtpA directs ETEC-blood group A interactions and stimulates ad2024-01-01T00:00:00Z2024 May2026-07-03T03:23:50.152Z2026-07-03T03:14:50.158ZS-EPMC111007053876609710.1101/2024.05.08.593125