biostudies-literatureUnknownSelby JVNCATS NIH HHS<h4>Background</h4>The PATH Statement (2020) proposed predictive modeling for examining heterogeneity in treatment effects (HTE) in randomized clinical trials (RCTs). It distinguished risk modeling, which develops a multivariable model predicting individual baseline risk of study outcomes and examines treatment effects across risk strata, from effect modeling, which directly estimates individual treatment effects from models that include treatment, multiple patient characteristics and interactions of treatment with selected characteristics.<h4>Purpose</h4>To identify, describe and evaluate findings from reports that cite the Statement and present predictive modeling of HTE in RCTs.<h4>Data extraction</h4>We identified reports using PubMed, Google Scholar, Web of Science, SCOPUS through JulmedRxiv : the preprint server for health sciences2024.05.06.24306774https://www.ebi.ac.uk/biostudies/studies/S-EPMC11100853biostudies-literaturePotential clinical impact of predictive modeling of heterogeneous treatment effects: scoping review of the impact of the PATH Statement.PMC11100853UM1 TR004398Selby JVFireman BHKent DMMaas CCHMfalsePotential clinical impact of predictive modeling of heterogeneous treatment effects: scoping review of the impact of the PATH Statement.<h4>Background</h4>The PATH Statement (2020) proposed predictive modeling for examining heterogeneity in treatment effects (HTE) in randomized clinical trials (RCTs). It distinguished risk modeling, which develops a multivariable model predicting individual baseline risk of study outcomes and examines treatment effects across risk strata, from effect modeling, which directly estimates individual treatment effects from models that include treatment, multiple patient characteristics and interactions of treatment with selected characteristics.<h4>Purpose</h4>To identify, describe and evaluate findings from reports that cite the Statement and present predictive modeling of HTE in RCTs.<h4>Data extraction</h4>We identified reports using PubMed, Google Scholar, Web of Science, SCOPUS through Jul2025-01-01T00:00:00Z2025 Feb2026-04-07T22:49:44.232Z2026-04-07T18:47:28.829ZS-EPMC111008533876615010.1101/2024.05.06.24306774