{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Baller EB"],"funding":["NIBIB NIH HHS","NIA NIH HHS","NIMH NIH HHS","NINDS NIH HHS"],"pagination":["1072-1080"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11101593"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["95(12)"],"pubmed_abstract":["Background
Multiple sclerosis (MS) is an immune-mediated neurological disorder, and up to 50% of patients experience depression. We investigated how white matter network disruption is related to depression in MS.Methods
Using electronic health records, 380 participants with MS were identified. Depressed individuals (MS+Depression group; n = 232) included persons who had an ICD-10 depression diagnosis, had a prescription for antidepressant medication, or screened positive via Patient Health Questionnaire (PHQ)-2 or PHQ-9. Age- and sex-matched nondepressed individuals with MS (MS-Depression group; n = 148) included persons who had no prior depression diagnosis, had no psychiatric medication prescriptions, and were asymptomatic on PHQ-2 or PHQ-9. Research-quality 3T structural"],"journal":["Biological psychiatry"],"pubmed_title":["Mapping the Relationship of White Matter Lesions to Depression in Multiple Sclerosis."],"pmcid":["PMC11101593"],"funding_grant_id":["R01 NS112274","R01 NS085211","R01 MH113550","R37 MH125829","RF1 MH116920","R01 MH123550","R00 MH127293","T32 MH019112","K23 MH133118","R01 MH120482","K99 MH127293","R01 MH112847","U24 NS130411","R01 EB022573","R21 AG070434","L30 MH127652"],"pubmed_authors":["Robert-Fitzgerald T","Shinohara RT","Bar-Or A","Sweeney EM","Fox MD","Rautman V","Baller EB","Cieslak M","Covitz SC","Larsen BS","Satterthwaite TD","Schindler MK","Markowitz CE","Perrone CM","Elahi A","Manning AR","Seitz MM","Detre JA","Martin ML"],"additional_accession":[]},"is_claimable":false,"name":"Mapping the Relationship of White Matter Lesions to Depression in Multiple Sclerosis.","description":"Background
Multiple sclerosis (MS) is an immune-mediated neurological disorder, and up to 50% of patients experience depression. We investigated how white matter network disruption is related to depression in MS.Methods
Using electronic health records, 380 participants with MS were identified. Depressed individuals (MS+Depression group; n = 232) included persons who had an ICD-10 depression diagnosis, had a prescription for antidepressant medication, or screened positive via Patient Health Questionnaire (PHQ)-2 or PHQ-9. Age- and sex-matched nondepressed individuals with MS (MS-Depression group; n = 148) included persons who had no prior depression diagnosis, had no psychiatric medication prescriptions, and were asymptomatic on PHQ-2 or PHQ-9. Research-quality 3T structural","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2025-07-26T03:07:11.039Z","creation":"2025-07-26T03:07:11.039Z"},"accession":"S-EPMC11101593","cross_references":{"pubmed":["37981178"],"doi":["10.1016/j.biopsych.2023.11.010"]}}