biostudies-literatureBaller EBNIBIB NIH HHSNIA NIH HHSNIMH NIH HHSNINDS NIH HHS1072-1080https://www.ebi.ac.uk/biostudies/studies/S-EPMC11101593biostudies-literatureUnknown95(12)<h4>Background</h4>Multiple sclerosis (MS) is an immune-mediated neurological disorder, and up to 50% of patients experience depression. We investigated how white matter network disruption is related to depression in MS.<h4>Methods</h4>Using electronic health records, 380 participants with MS were identified. Depressed individuals (MS+Depression group; n = 232) included persons who had an ICD-10 depression diagnosis, had a prescription for antidepressant medication, or screened positive via Patient Health Questionnaire (PHQ)-2 or PHQ-9. Age- and sex-matched nondepressed individuals with MS (MS-Depression group; n = 148) included persons who had no prior depression diagnosis, had no psychiatric medication prescriptions, and were asymptomatic on PHQ-2 or PHQ-9. Research-quality 3T structuralBiological psychiatryMapping the Relationship of White Matter Lesions to Depression in Multiple Sclerosis.PMC11101593R01 NS112274R01 NS085211R01 MH113550R37 MH125829RF1 MH116920R01 MH123550R00 MH127293T32 MH019112K23 MH133118R01 MH120482K99 MH127293R01 MH112847U24 NS130411R01 EB022573R21 AG070434L30 MH127652Robert-Fitzgerald TShinohara RTBar-Or ASweeney EMFox MDRautman VBaller EBCieslak MCovitz SCLarsen BSSatterthwaite TDSchindler MKMarkowitz CEPerrone CMElahi AManning ARSeitz MMDetre JAMartin MLfalseMapping the Relationship of White Matter Lesions to Depression in Multiple Sclerosis.<h4>Background</h4>Multiple sclerosis (MS) is an immune-mediated neurological disorder, and up to 50% of patients experience depression. We investigated how white matter network disruption is related to depression in MS.<h4>Methods</h4>Using electronic health records, 380 participants with MS were identified. Depressed individuals (MS+Depression group; n = 232) included persons who had an ICD-10 depression diagnosis, had a prescription for antidepressant medication, or screened positive via Patient Health Questionnaire (PHQ)-2 or PHQ-9. Age- and sex-matched nondepressed individuals with MS (MS-Depression group; n = 148) included persons who had no prior depression diagnosis, had no psychiatric medication prescriptions, and were asymptomatic on PHQ-2 or PHQ-9. Research-quality 3T structural2024-01-01T00:00:00Z2024 Jun2025-07-26T03:07:11.039Z2025-07-26T03:07:11.039ZS-EPMC111015933798117810.1016/j.biopsych.2023.11.010