{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(3)"],"submitter":["Pachimsawat P"],"funding":["Mahidol University"],"pubmed_abstract":["This study aimed to examine the effect of acute exogenous melatonin administration on salivary cortisol and alpha-amylase (sCort and sAA) as representatives of the HPA axis and the sympathetic nervous system, respectively. A single-dose prolonged-release melatonin (2 mg) or a placebo tablet was given to healthy volunteers (n = 64) at 20:00 h in a crossover design. The saliva was collected at six time points (20:00, 21:00, awakening, 30 min after awakening, 10:00, and 12:00 h) and was measured for sCort, sAA, and salivary melatonin (sMT) levels. Pulse rates and sleep parameters were also collected. Melatonin was effective in improving sleep onset latency by 7:04 min (p = .037) and increasing total sleep time by 24 min (p = .006). Participants with poor baseline sleep quality responded more "],"journal":["Pharmacology research & perspectives"],"pagination":["e1205"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11103136"],"repository":["biostudies-literature"],"pubmed_title":["Exogenous melatonin's effect on salivary cortisol and amylase: A randomized controlled trial."],"pmcid":["PMC11103136"],"pubmed_authors":["Jantaratnotai N","Pachimsawat P","Ratanachamnong P"],"additional_accession":[]},"is_claimable":false,"name":"Exogenous melatonin's effect on salivary cortisol and amylase: A randomized controlled trial.","description":"This study aimed to examine the effect of acute exogenous melatonin administration on salivary cortisol and alpha-amylase (sCort and sAA) as representatives of the HPA axis and the sympathetic nervous system, respectively. A single-dose prolonged-release melatonin (2 mg) or a placebo tablet was given to healthy volunteers (n = 64) at 20:00 h in a crossover design. The saliva was collected at six time points (20:00, 21:00, awakening, 30 min after awakening, 10:00, and 12:00 h) and was measured for sCort, sAA, and salivary melatonin (sMT) levels. Pulse rates and sleep parameters were also collected. Melatonin was effective in improving sleep onset latency by 7:04 min (p = .037) and increasing total sleep time by 24 min (p = .006). Participants with poor baseline sleep quality responded more ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-07-16T07:30:43.096Z","creation":"2026-07-09T10:43:16.803Z"},"accession":"S-EPMC11103136","cross_references":{"pubmed":["38764237"],"doi":["10.1002/prp2.1205"]}}