biostudies-literatureUnknown12(3)Pachimsawat PMahidol UniversityThis study aimed to examine the effect of acute exogenous melatonin administration on salivary cortisol and alpha-amylase (sCort and sAA) as representatives of the HPA axis and the sympathetic nervous system, respectively. A single-dose prolonged-release melatonin (2 mg) or a placebo tablet was given to healthy volunteers (n = 64) at 20:00 h in a crossover design. The saliva was collected at six time points (20:00, 21:00, awakening, 30 min after awakening, 10:00, and 12:00 h) and was measured for sCort, sAA, and salivary melatonin (sMT) levels. Pulse rates and sleep parameters were also collected. Melatonin was effective in improving sleep onset latency by 7:04 min (p = .037) and increasing total sleep time by 24 min (p = .006). Participants with poor baseline sleep quality responded more Pharmacology research & perspectivese1205https://www.ebi.ac.uk/biostudies/studies/S-EPMC11103136biostudies-literatureExogenous melatonin's effect on salivary cortisol and amylase: A randomized controlled trial.PMC11103136Jantaratnotai NPachimsawat PRatanachamnong PfalseExogenous melatonin's effect on salivary cortisol and amylase: A randomized controlled trial.This study aimed to examine the effect of acute exogenous melatonin administration on salivary cortisol and alpha-amylase (sCort and sAA) as representatives of the HPA axis and the sympathetic nervous system, respectively. A single-dose prolonged-release melatonin (2 mg) or a placebo tablet was given to healthy volunteers (n = 64) at 20:00 h in a crossover design. The saliva was collected at six time points (20:00, 21:00, awakening, 30 min after awakening, 10:00, and 12:00 h) and was measured for sCort, sAA, and salivary melatonin (sMT) levels. Pulse rates and sleep parameters were also collected. Melatonin was effective in improving sleep onset latency by 7:04 min (p = .037) and increasing total sleep time by 24 min (p = .006). Participants with poor baseline sleep quality responded more 2024-01-01T00:00:00Z2024 Jun2026-07-16T07:30:43.096Z2026-07-09T10:43:16.803ZS-EPMC111031363876423710.1002/prp2.1205