{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Klingler J"],"funding":["BLRD VA","NIAID NIH HHS","National Institutes of Health","U.S. Department of Veterans Affairs"],"pagination":["1382619"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11109367"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15"],"pubmed_abstract":["<h4>Introduction</h4>Antibodies against the SARS-CoV-2 spike protein are a critical immune determinant for protection against the virus. While virus neutralization is a key function of spike-specific antibodies, antibodies also mediate Fc-dependent activities that can play a role in protection or pathogenesis.<h4>Methods</h4>This study characterized serum antibody responses elicited after two doses of heterologous adenovirus-vectored (Ad26/ Ad5) vaccines.<h4>Results</h4>Vaccine-induced antibody binding titers and Fc-mediated functions decreased over six months, while neutralization titers remained stable. Comparison of antibody isotypes elicited after Ad26/Ad5 vs. LNP-mRNA vaccination and after infection showed that anti-spike IgG1 were dominant and produced to high levels in all groups. T"],"journal":["Frontiers in immunology"],"pubmed_title":["Heterologous Ad26/Ad5 adenovirus-vectored vaccines elicited SARS-CoV-2-specific antibody responses with potent Fc activities."],"pmcid":["PMC11109367"],"funding_grant_id":["IK6 BX004607","HHSN272201400008C","75N93019C00051","R01 AI140909","R21 AI148033","R21 AI149033","U01 AI141990","U01 AI150747","R01 AI123449","I01 BX005794","R01 AI139290","AI139290, AI123449, AI1498033, 75N93019C00051, HHSN272201400008C, HHSN272201400006C, AI141990, AI150747, AI140909","I01BX005794, 1IK6BX004607","HHSN272201400006C"],"pubmed_authors":["Emami-Gorizi R","Rao PG","Alvarez RA","Amanat F","Gleason C","Upadhyay C","Simon V","Kowdle S","Lee B","Klingler J","Perandones C","Hioe CE","Bandres JC","Kleiner G","Edelstein A"],"additional_accession":[]},"is_claimable":false,"name":"Heterologous Ad26/Ad5 adenovirus-vectored vaccines elicited SARS-CoV-2-specific antibody responses with potent Fc activities.","description":"<h4>Introduction</h4>Antibodies against the SARS-CoV-2 spike protein are a critical immune determinant for protection against the virus. While virus neutralization is a key function of spike-specific antibodies, antibodies also mediate Fc-dependent activities that can play a role in protection or pathogenesis.<h4>Methods</h4>This study characterized serum antibody responses elicited after two doses of heterologous adenovirus-vectored (Ad26/ Ad5) vaccines.<h4>Results</h4>Vaccine-induced antibody binding titers and Fc-mediated functions decreased over six months, while neutralization titers remained stable. Comparison of antibody isotypes elicited after Ad26/Ad5 vs. LNP-mRNA vaccination and after infection showed that anti-spike IgG1 were dominant and produced to high levels in all groups. T","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-04-12T19:09:43.355Z","creation":"2026-04-08T03:17:56.223Z"},"accession":"S-EPMC11109367","cross_references":{"pubmed":["38779671"],"doi":["10.3389/fimmu.2024.1382619"]}}