{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Salazar M"],"funding":["Consejo Superior de Investigaciones Científicas","Agencia Estatal de Investigación","the Spanish Ministry of Science and Innovation"],"pagination":["e0300310"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11111069"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(5)"],"pubmed_abstract":["Gravity is one of the most constant environmental factors across Earth's evolution and all organisms are adapted to it. Consequently, spatial exploration has captured the interest in studying the biological changes that physiological alterations are caused by gravity. In the last two decades, epigenetics has explained how environmental cues can alter gene functions in organisms. Although many studies addressed gravity, the underlying biological and molecular mechanisms that occur in altered gravity for those epigenetics-related mechanisms, are mostly inexistent. The present study addressed the effects of hypergravity on development, behavior, gene expression, and most importantly, on the epigenetic changes in a worldwide animal model, the zebrafish (Danio rerio). To perform hypergravity ex"],"journal":["PloS one"],"pubmed_title":["Epigenetic and physiological alterations in zebrafish subjected to hypergravity."],"pmcid":["PMC11111069"],"funding_grant_id":["RYC-2017-22489","02030E004","2PID2020-113781RB-I00"],"pubmed_authors":["Joly S","Ribas L","Anglada-Escude G","Salazar M"],"additional_accession":[]},"is_claimable":false,"name":"Epigenetic and physiological alterations in zebrafish subjected to hypergravity.","description":"Gravity is one of the most constant environmental factors across Earth's evolution and all organisms are adapted to it. Consequently, spatial exploration has captured the interest in studying the biological changes that physiological alterations are caused by gravity. In the last two decades, epigenetics has explained how environmental cues can alter gene functions in organisms. Although many studies addressed gravity, the underlying biological and molecular mechanisms that occur in altered gravity for those epigenetics-related mechanisms, are mostly inexistent. The present study addressed the effects of hypergravity on development, behavior, gene expression, and most importantly, on the epigenetic changes in a worldwide animal model, the zebrafish (Danio rerio). To perform hypergravity ex","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-07-15T08:20:59.689Z","creation":"2026-07-01T03:12:05.039Z"},"accession":"S-EPMC11111069","cross_references":{"pubmed":["38776274"],"doi":["10.1371/journal.pone.0300310"]}}