{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(6)"],"submitter":["Dos Santos PCP"],"funding":["Bill &amp; Melinda Gates Foundation","The Royal Children&apos;s Hospital Foundation","Minderoo Foundation"],"pubmed_abstract":["<h4>Background</h4>The effectiveness of BCG vaccine for adult pulmonary tuberculosis remains uncertain. In this study, we aimed to evaluate the effect of vaccination with BCG-Denmark to prevent initial and sustained interferon-γ release assay conversion in Brazilian health-care workers.<h4>Methods</h4>This substudy is a nested randomised controlled trial embedded within the BRACE trial (NCT04327206). Specifically, this substudy enrolled Brazilian health-care workers (aged ≥18 years) from three sites in Brazil (Manaus, Campo Grande, and Rio de Janeiro) irrespective of previously receiving BCG vaccination. Participants were excluded if they had contraindications to BCG vaccination, more than 1 month of treatment with specific tuberculosis treatment drugs, previous adverse reactions to BCG, r"],"journal":["The Lancet. Infectious diseases"],"pagination":["594-601"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11111441"],"repository":["biostudies-literature"],"pubmed_title":["Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial."],"pmcid":["PMC11111441"],"pubmed_authors":["Dalcolmo M","Andrews JR","Messina NL","Curtis N","Jardim BA","Dos Santos PCP","Croda J","da Silva PV","de Lacerda MVG","Puga MAM","Dos Santos G","de Almeida E Val FF","de Oliveira RD"],"additional_accession":[]},"is_claimable":false,"name":"Effect of BCG vaccination against Mycobacterium tuberculosis infection in adult Brazilian health-care workers: a nested clinical trial.","description":"<h4>Background</h4>The effectiveness of BCG vaccine for adult pulmonary tuberculosis remains uncertain. In this study, we aimed to evaluate the effect of vaccination with BCG-Denmark to prevent initial and sustained interferon-γ release assay conversion in Brazilian health-care workers.<h4>Methods</h4>This substudy is a nested randomised controlled trial embedded within the BRACE trial (NCT04327206). Specifically, this substudy enrolled Brazilian health-care workers (aged ≥18 years) from three sites in Brazil (Manaus, Campo Grande, and Rio de Janeiro) irrespective of previously receiving BCG vaccination. Participants were excluded if they had contraindications to BCG vaccination, more than 1 month of treatment with specific tuberculosis treatment drugs, previous adverse reactions to BCG, r","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2026-06-02T08:22:46.7Z","creation":"2026-05-26T03:07:17.828Z"},"accession":"S-EPMC11111441","cross_references":{"pubmed":["38423021"],"doi":["10.1016/S1473-3099(23)00818-6"]}}