biostudies-literatureZeng Wthe National Key Research and Development Program of Chinathe National Natural Science Foundation of China1573-1585https://www.ebi.ac.uk/biostudies/studies/S-EPMC11111573biostudies-literatureUnknown31(6)Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease, which can lead to adverse fetal outcomes, including preterm labor and intrauterine death. The pathogenesis of ICP is still unclear. We hypothesized that pathological index leads to abnormal placenta changes in ICP. Investigation of these differences in protein expression in parallel profiling is essential to understand the comprehensive pathophysiological mechanism underlying ICP. The present study screened differentially expressed proteins (DEPs) as novel diagnostic markers for ICP. Proteomic profiles of placental tissues from 32 ICP patients and 24 healthy volunteers (controls) were analyzed. Our founding was valid by following western blotting and immunohistochemistry staining, respectively. The associatiReproductive sciences (Thousand Oaks, Calif.)Proteomic Biomarkers of Intrahepatic Cholestasis of Pregnancy.PMC111115732019YFA080260481861128021Chen ZGu WZeng WHou YfalseProteomic Biomarkers of Intrahepatic Cholestasis of Pregnancy.Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific liver disease, which can lead to adverse fetal outcomes, including preterm labor and intrauterine death. The pathogenesis of ICP is still unclear. We hypothesized that pathological index leads to abnormal placenta changes in ICP. Investigation of these differences in protein expression in parallel profiling is essential to understand the comprehensive pathophysiological mechanism underlying ICP. The present study screened differentially expressed proteins (DEPs) as novel diagnostic markers for ICP. Proteomic profiles of placental tissues from 32 ICP patients and 24 healthy volunteers (controls) were analyzed. Our founding was valid by following western blotting and immunohistochemistry staining, respectively. The associati2024-01-01T00:00:00Z2024 Jun2026-07-02T03:13:33.29Z2026-07-02T03:09:02.171ZS-EPMC111115733817794910.1007/s43032-023-01437-z