biostudies-literatureUnknown206(5)Orozco RMQBovine mastitis is a frequent infection in lactating cattle, causing great economic losses. <i>Staphylococcus aureus</i> represents the main etiological agent, which causes recurrent and persistent intramammary infections because conventional antibiotics are ineffective against it. Mastoparan-like peptides are multifunctional molecules with broad antimicrobial potential, constituting an attractive alternative. Nevertheless, their toxicity to host cells has hindered their therapeutic application. Previously, our group engineered three mastoparan-L analogs, namely mastoparan-MO, mastoparan-R1, and [I⁵, R⁸] MP, to improve cell selectivity and potential. Here, we were interested in comparing the antibacterial efficacy of mastoparan-L and its analogs against bovine mastitiJournal of bacteriologye0007124https://www.ebi.ac.uk/biostudies/studies/S-EPMC11112992biostudies-literatureEmployment of mastoparan-like peptides to prevent &lt;i&gt;Staphylococcus aureus&lt;/i&gt; associated with bovine mastitis.PMC11112992Oshiro KGNAlmeida CVde Souza CMOrozco RMQMacedo MLRFranco OLMarin VNCardoso MHPinto IBBuccini DFfalseEmployment of mastoparan-like peptides to prevent &lt;i&gt;Staphylococcus aureus&lt;/i&gt; associated with bovine mastitis.Bovine mastitis is a frequent infection in lactating cattle, causing great economic losses. <i>Staphylococcus aureus</i> represents the main etiological agent, which causes recurrent and persistent intramammary infections because conventional antibiotics are ineffective against it. Mastoparan-like peptides are multifunctional molecules with broad antimicrobial potential, constituting an attractive alternative. Nevertheless, their toxicity to host cells has hindered their therapeutic application. Previously, our group engineered three mastoparan-L analogs, namely mastoparan-MO, mastoparan-R1, and [I⁵, R⁸] MP, to improve cell selectivity and potential. Here, we were interested in comparing the antibacterial efficacy of mastoparan-L and its analogs against bovine mastiti2024-01-01T00:00:00Z2024 May2025-04-26T07:51:06.695Z2025-04-06T12:29:59.193ZS-EPMC111129923862987510.1128/jb.00071-24