{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kumar A"],"funding":["BLRD VA","The Department of Veterans Affairs VA Merit Review","NIAID NIH HHS","NIH","NIH HHS"],"pagination":["e0002424"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11112993"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["206(5)"],"pubmed_abstract":["Microbes synthesize and secrete siderophores, that bind and solubilize precipitated or otherwise unavailable iron in their microenvironments. Gram (-) bacterial TonB-dependent outer membrane receptors capture the resulting ferric siderophores to begin the uptake process. From their similarity to <i>fepA,</i> the structural gene for the <i>Escherichia coli</i> ferric enterobactin (FeEnt) receptor, we identified four homologous genes in the human and animal ESKAPE pathogen <i>Klebsiella pneumoniae</i> (strain Kp52.145). One locus encodes IroN (locus <i>0027</i> on plasmid pII), and three other loci encode other FepA orthologs/paralogs (chromosomal loci <i>1658, 2380,</i> and <i>4984</i>). Based on the crystal structure of <i>E. coli</i> FepA (1FEP), we modeled the tertiary structures of the "],"journal":["Journal of bacteriology"],"pubmed_title":["Siderophore-mediated iron acquisition by <i>Klebsiella pneumoniae</i>."],"pmcid":["PMC11112993"],"funding_grant_id":["I01 BX004677","R21 AI141826","R21 AI088318","R21 AI123558","I01 BX004677-01","R21 AI123558-01 and 1R21AI141826-01A1"],"pubmed_authors":["Newton SM","Chakravorty S","Klebba PE","Yang T","Kumar A","Russo TA"],"additional_accession":[]},"is_claimable":false,"name":"Siderophore-mediated iron acquisition by <i>Klebsiella pneumoniae</i>.","description":"Microbes synthesize and secrete siderophores, that bind and solubilize precipitated or otherwise unavailable iron in their microenvironments. Gram (-) bacterial TonB-dependent outer membrane receptors capture the resulting ferric siderophores to begin the uptake process. From their similarity to <i>fepA,</i> the structural gene for the <i>Escherichia coli</i> ferric enterobactin (FeEnt) receptor, we identified four homologous genes in the human and animal ESKAPE pathogen <i>Klebsiella pneumoniae</i> (strain Kp52.145). One locus encodes IroN (locus <i>0027</i> on plasmid pII), and three other loci encode other FepA orthologs/paralogs (chromosomal loci <i>1658, 2380,</i> and <i>4984</i>). Based on the crystal structure of <i>E. coli</i> FepA (1FEP), we modeled the tertiary structures of the ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-13T05:39:49.323Z","creation":"2025-04-06T12:30:29.059Z"},"accession":"S-EPMC11112993","cross_references":{"pubmed":["38591913"],"doi":["10.1128/jb.00024-24"]}}