{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Beucke JC"],"funding":["NCATS NIH HHS","NCRR NIH HHS","NIMH NIH HHS"],"pagination":["230-237"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11113072"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["171"],"pubmed_abstract":["Animal models suggest that experiencing high-stress levels induces changes in amygdalar circuitry and gene expression. In humans, combat exposure has been shown to alter amygdalar responsivity and connectivity, but abnormalities have been indicated to normalize at least partially upon the termination of stress exposure. In contrast, other evidence suggests that combat exposure continues to exert influence on exposed individuals well beyond deployment and homecoming, as indicated by longitudinal psychosocial evidence from veterans, and observation of greater health decline in veterans late in life. Accordingly, the experience of combat stress early in life may affect amygdalar responsivity late in life, a possibility requiring careful consideration of the confounding effects of aging, genet"],"journal":["Journal of psychiatric research"],"pubmed_title":["A late-life neurogenetic signature of exposure to combat stress - A monozygotic discordant twin study."],"pmcid":["PMC11113072"],"funding_grant_id":["UL1 RR025758","UL1 TR001102","P41 RR014075","UL1 TR000170","R01 MH054636"],"pubmed_authors":["Pitman RK","Shin LM","Diez I","Sepulcre J","Mundorf A","Orr SP","Beucke JC","Kaufmann C"],"additional_accession":[]},"is_claimable":false,"name":"A late-life neurogenetic signature of exposure to combat stress - A monozygotic discordant twin study.","description":"Animal models suggest that experiencing high-stress levels induces changes in amygdalar circuitry and gene expression. In humans, combat exposure has been shown to alter amygdalar responsivity and connectivity, but abnormalities have been indicated to normalize at least partially upon the termination of stress exposure. In contrast, other evidence suggests that combat exposure continues to exert influence on exposed individuals well beyond deployment and homecoming, as indicated by longitudinal psychosocial evidence from veterans, and observation of greater health decline in veterans late in life. Accordingly, the experience of combat stress early in life may affect amygdalar responsivity late in life, a possibility requiring careful consideration of the confounding effects of aging, genet","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2025-04-03T23:36:27.058Z","creation":"2025-04-03T23:36:27.058Z"},"accession":"S-EPMC11113072","cross_references":{"pubmed":["38316103"],"doi":["10.1016/j.jpsychires.2024.01.032"]}}