{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["70(9)"],"submitter":["Alessio N"],"pubmed_abstract":["Stem cell senescence is considered deleterious because it may impair tissue renewal and function. On the other hand, senescence may arrest the uncontrolled growth of transformed stem cells and protect organisms from cancer. This double function of senescence is strictly linked to the activity of genes that the control cell cycle such as the retinoblastoma proteins RB1, RB2/P130, and P107. We took advantage of the RNA interference technique to analyze the role of these proteins in the biology of mesenchymal stem cells (MSC). Cells lacking RB1 were prone to DNA damage. They showed elevated levels of p53 and p21(cip1) and increased regulation of RB2/P130 and P107 expression. These cells gradually adopted a senescent phenotype with impairment of self-renewal properties. No significant modifica"],"journal":["Cellular and molecular life sciences : CMLS"],"pagination":["1637-51"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11113310"],"repository":["biostudies-literature"],"pubmed_title":["Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells."],"pmcid":["PMC11113310"],"pubmed_authors":["Cipollaro M","Giordano A","Galderisi U","Bohn W","Alessio N","Rosemann M","Beckers J","Rauchberger V","Rizzolio F","Irmler M"],"additional_accession":[]},"is_claimable":false,"name":"Silencing of RB1 but not of RB2/P130 induces cellular senescence and impairs the differentiation potential of human mesenchymal stem cells.","description":"Stem cell senescence is considered deleterious because it may impair tissue renewal and function. On the other hand, senescence may arrest the uncontrolled growth of transformed stem cells and protect organisms from cancer. This double function of senescence is strictly linked to the activity of genes that the control cell cycle such as the retinoblastoma proteins RB1, RB2/P130, and P107. We took advantage of the RNA interference technique to analyze the role of these proteins in the biology of mesenchymal stem cells (MSC). Cells lacking RB1 were prone to DNA damage. They showed elevated levels of p53 and p21(cip1) and increased regulation of RB2/P130 and P107 expression. These cells gradually adopted a senescent phenotype with impairment of self-renewal properties. No significant modifica","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 May","modification":"2026-06-01T20:17:50.761Z","creation":"2026-05-20T03:09:01.821Z"},"accession":"S-EPMC11113310","cross_references":{"pubmed":["23370776"],"doi":["10.1007/s00018-012-1224-x"]}}