{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu C"],"funding":["National Key R&D Program of China","Natural Science Foundation of Guangdong Province","National Natural Science Foundation of China","Ministry of Science and Technology, P.R.China","Guangzhou Basic and Applied Basic Research Foundation","The Key Research and Development Program of the Ministry of Science and Technology"],"pagination":["e14109"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11113349"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(5)"],"pubmed_abstract":["Brain aging is associated with cognitive decline, memory loss and many neurodegenerative disorders. The mammalian brain has distinct structural regions that perform specific functions. However, our understanding in gene expression and cell types within the context of the spatial organization of the mammalian aging brain is limited. Here we generated spatial transcriptomic maps of young and old mouse brains. We identified 27 distinguished brain spatial domains, including layer-specific subregions that are difficult to dissect individually. We comprehensively characterized spatial-specific changes in gene expression in the aging brain, particularly for isocortex, the hippocampal formation, brainstem and fiber tracts, and validated some gene expression differences by qPCR and immunohistochemi"],"journal":["Aging cell"],"pubmed_title":["Spatially resolved transcriptome of the aging mouse brain."],"pmcid":["PMC11113349"],"funding_grant_id":["820712002","82171404","202201020336","2021YFF1200903","2023A1515011529","81790640","2022YFF1202901","2022ZD0208604","2022ZD0208605","31771195"],"pubmed_authors":["Tu T","Zhang J","Xie Z","Wu C","Xie M","Yan B","Wang Y","Gong Y","Zhou X"],"additional_accession":[]},"is_claimable":false,"name":"Spatially resolved transcriptome of the aging mouse brain.","description":"Brain aging is associated with cognitive decline, memory loss and many neurodegenerative disorders. The mammalian brain has distinct structural regions that perform specific functions. However, our understanding in gene expression and cell types within the context of the spatial organization of the mammalian aging brain is limited. Here we generated spatial transcriptomic maps of young and old mouse brains. We identified 27 distinguished brain spatial domains, including layer-specific subregions that are difficult to dissect individually. We comprehensively characterized spatial-specific changes in gene expression in the aging brain, particularly for isocortex, the hippocampal formation, brainstem and fiber tracts, and validated some gene expression differences by qPCR and immunohistochemi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-01T10:58:44.314Z","creation":"2026-04-08T11:39:24.967Z"},"accession":"S-EPMC11113349","cross_references":{"pubmed":["38372175"],"doi":["10.1111/acel.14109"]}}