{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["71(13)"],"submitter":["Han J"],"pubmed_abstract":["The gamma (γ)-secretase holoenzyme is composed of four core proteins and cleaves APP to generate amyloid beta (Aβ), a key molecule that causes major neurotoxicity during the early stage of Alzheimer's disease (AD). However, despite its important role in Aβ production, little is known about the regulation of γ-secretase. OCIAD2, a novel modulator of γ-secretase that stimulates Aβ production, and which was isolated from a genome-wide functional screen using cell-based assays and a cDNA library comprising 6,178 genes. Ectopic expression of OCIAD2 enhanced Aβ production, while reduction of OCIAD2 expression suppressed it. OCIAD2 expression facilitated the formation of an active γ-secretase complex and enhanced subcellular localization of the enzyme components to lipid rafts. OCIAD2 interacted "],"journal":["Cellular and molecular life sciences : CMLS"],"pagination":["2561-76"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11113593"],"repository":["biostudies-literature"],"pubmed_title":["OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin."],"pmcid":["PMC11113593"],"pubmed_authors":["Choi H","Nah J","Nishimura M","Kam TI","Han J","Jang J","Jo DG","Nakagawa T","Kim BJ","Jung S","Jung YK"],"additional_accession":[]},"is_claimable":false,"name":"OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin.","description":"The gamma (γ)-secretase holoenzyme is composed of four core proteins and cleaves APP to generate amyloid beta (Aβ), a key molecule that causes major neurotoxicity during the early stage of Alzheimer's disease (AD). However, despite its important role in Aβ production, little is known about the regulation of γ-secretase. OCIAD2, a novel modulator of γ-secretase that stimulates Aβ production, and which was isolated from a genome-wide functional screen using cell-based assays and a cDNA library comprising 6,178 genes. Ectopic expression of OCIAD2 enhanced Aβ production, while reduction of OCIAD2 expression suppressed it. OCIAD2 expression facilitated the formation of an active γ-secretase complex and enhanced subcellular localization of the enzyme components to lipid rafts. OCIAD2 interacted ","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jul","modification":"2026-04-12T19:23:54.296Z","creation":"2026-04-07T13:17:23.907Z"},"accession":"S-EPMC11113593","cross_references":{"pubmed":["24270855"],"doi":["10.1007/s00018-013-1515-x"]}}