{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["70(19)"],"submitter":["Maixner F"],"pubmed_abstract":["The Tyrolean Iceman, a Copper-age ice mummy, is one of the best-studied human individuals. While the genome of the Iceman has largely been decoded, tissue-specific proteomes have not yet been investigated. We studied the proteome of two distinct brain samples using gel-based and liquid chromatography-mass spectrometry-based proteomics technologies together with a multiple-databases and -search algorithms-driven data-analysis approach. Thereby, we identified a total of 502 different proteins. Of these, 41 proteins are known to be highly abundant in brain tissue and 9 are even specifically expressed in the brain. Furthermore, we found 10 proteins related to blood and coagulation. An enrichment analysis revealed a significant accumulation of proteins related to stress response and wound heali"],"journal":["Cellular and molecular life sciences : CMLS"],"pagination":["3709-22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11113858"],"repository":["biostudies-literature"],"pubmed_title":["Paleoproteomic study of the Iceman's brain tissue."],"pmcid":["PMC11113858"],"pubmed_authors":["Schwarz A","Zink A","Maixner F","Overath T","Linke D","Franke A","Guerriero G","van den Berg BH","Leidinger P","Tholey A","Meder B","Keller A","Backes C","Egarter-Vigl E","Meese E","Janko M","Kneissl B","Stade B","Jaremek M"],"additional_accession":[]},"is_claimable":false,"name":"Paleoproteomic study of the Iceman's brain tissue.","description":"The Tyrolean Iceman, a Copper-age ice mummy, is one of the best-studied human individuals. While the genome of the Iceman has largely been decoded, tissue-specific proteomes have not yet been investigated. We studied the proteome of two distinct brain samples using gel-based and liquid chromatography-mass spectrometry-based proteomics technologies together with a multiple-databases and -search algorithms-driven data-analysis approach. Thereby, we identified a total of 502 different proteins. Of these, 41 proteins are known to be highly abundant in brain tissue and 9 are even specifically expressed in the brain. Furthermore, we found 10 proteins related to blood and coagulation. An enrichment analysis revealed a significant accumulation of proteins related to stress response and wound heali","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Oct","modification":"2026-06-03T06:54:00.456Z","creation":"2026-04-25T03:22:31.244Z"},"accession":"S-EPMC11113858","cross_references":{"pubmed":["23739949"],"doi":["10.1007/s00018-013-1360-y"]}}