{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["71(9)"],"submitter":["Wu Y"],"pubmed_abstract":["Blastomere biopsy is used in preimplantation genetic diagnosis; however, the long-term implications on the offspring are poorly characterized. We previously reported a high risk of memory defects in adult biopsied mice. Here, we assessed nervous function of aged biopsied mice and further investigated the mechanism of neural impairment after biopsy. We found that aged biopsied mice had poorer spatial learning ability, increased neuron degeneration, and altered expression of proteins involved in neural degeneration or dysfunction in the brain compared to aged control mice. Furthermore, the MeDIP assay indicated a genome-wide low methylation in the brains of adult biopsied mice when compared to the controls, and most of the genes containing differentially methylated loci in promoter regions w"],"journal":["Cellular and molecular life sciences : CMLS"],"pagination":["1761-74"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11114061"],"repository":["biostudies-literature"],"pubmed_title":["Blastomere biopsy influences epigenetic reprogramming during early embryo development, which impacts neural development and function in resulting mice."],"pmcid":["PMC11114061"],"pubmed_authors":["Lv Z","Dong G","Yang Y","Zhou Q","Sha J","Cui Y","Tong M","Zhu H","Wu Y","Yu Y","Wang L","Zhou Z"],"additional_accession":[]},"is_claimable":false,"name":"Blastomere biopsy influences epigenetic reprogramming during early embryo development, which impacts neural development and function in resulting mice.","description":"Blastomere biopsy is used in preimplantation genetic diagnosis; however, the long-term implications on the offspring are poorly characterized. We previously reported a high risk of memory defects in adult biopsied mice. Here, we assessed nervous function of aged biopsied mice and further investigated the mechanism of neural impairment after biopsy. We found that aged biopsied mice had poorer spatial learning ability, increased neuron degeneration, and altered expression of proteins involved in neural degeneration or dysfunction in the brain compared to aged control mice. Furthermore, the MeDIP assay indicated a genome-wide low methylation in the brains of adult biopsied mice when compared to the controls, and most of the genes containing differentially methylated loci in promoter regions w","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 May","modification":"2026-06-02T08:28:46.361Z","creation":"2026-04-16T03:11:36.626Z"},"accession":"S-EPMC11114061","cross_references":{"pubmed":["24037382"],"doi":["10.1007/s00018-013-1466-2"]}}