{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Rodriguez S"],"funding":["Institut National Du Cancer"],"pubmed_abstract":["<h4>Introduction</h4>Follicular Lymphoma (FL) results from the malignant transformation of germinal center (GC) B cells. FL B cells display recurrent and diverse genetic alterations, some of them favoring their direct interaction with their cell microenvironment, including follicular helper T cells (Tfh). Although FL-Tfh key role is well-documented, the impact of their regulatory counterpart, the follicular regulatory T cell (Tfr) compartment, is still sparse.<h4>Methods</h4>The aim of this study was to characterize FL-Tfr phenotype by cytometry, gene expression profile, FL-Tfr origin by transcriptomic analysis, and functionality by in vitro assays.<h4>Results</h4>CD4<sup>+</sup>CXCR5<sup>+</sup>CD25<sup>hi</sup>ICOS<sup>+</sup> FL-Tfr displayed a regulatory program that is close to classi"],"journal":["Frontiers in immunology"],"pagination":["1391404"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11116630"],"repository":["biostudies-literature"],"pubmed_title":["Follicular lymphoma regulatory T-cell origin and function."],"pmcid":["PMC11116630"],"pubmed_authors":["Alizadeh M","Martin-Subero JI","Cogne M","Ame-Thomas P","Pangault C","Rodriguez S","Lamaison C","Jean R","Saintamand A","Monvoisin C","Deleurme L","Tarte K"],"additional_accession":[]},"is_claimable":false,"name":"Follicular lymphoma regulatory T-cell origin and function.","description":"<h4>Introduction</h4>Follicular Lymphoma (FL) results from the malignant transformation of germinal center (GC) B cells. FL B cells display recurrent and diverse genetic alterations, some of them favoring their direct interaction with their cell microenvironment, including follicular helper T cells (Tfh). Although FL-Tfh key role is well-documented, the impact of their regulatory counterpart, the follicular regulatory T cell (Tfr) compartment, is still sparse.<h4>Methods</h4>The aim of this study was to characterize FL-Tfr phenotype by cytometry, gene expression profile, FL-Tfr origin by transcriptomic analysis, and functionality by in vitro assays.<h4>Results</h4>CD4<sup>+</sup>CXCR5<sup>+</sup>CD25<sup>hi</sup>ICOS<sup>+</sup> FL-Tfr displayed a regulatory program that is close to classi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T21:51:48.638Z","creation":"2026-05-21T03:09:12.835Z"},"accession":"S-EPMC11116630","cross_references":{"pubmed":["38799444"],"doi":["10.3389/fimmu.2024.1391404"]}}