biostudies-literatureUnknown15Rodriguez SInstitut National Du Cancer<h4>Introduction</h4>Follicular Lymphoma (FL) results from the malignant transformation of germinal center (GC) B cells. FL B cells display recurrent and diverse genetic alterations, some of them favoring their direct interaction with their cell microenvironment, including follicular helper T cells (Tfh). Although FL-Tfh key role is well-documented, the impact of their regulatory counterpart, the follicular regulatory T cell (Tfr) compartment, is still sparse.<h4>Methods</h4>The aim of this study was to characterize FL-Tfr phenotype by cytometry, gene expression profile, FL-Tfr origin by transcriptomic analysis, and functionality by in vitro assays.<h4>Results</h4>CD4⁺CXCR5⁺CD25^hiICOS⁺ FL-Tfr displayed a regulatory program that is close to classiFrontiers in immunology1391404https://www.ebi.ac.uk/biostudies/studies/S-EPMC11116630biostudies-literatureFollicular lymphoma regulatory T-cell origin and function.PMC11116630Alizadeh MMartin-Subero JICogne MAme-Thomas PPangault CRodriguez SLamaison CJean RSaintamand AMonvoisin CDeleurme LTarte KfalseFollicular lymphoma regulatory T-cell origin and function.<h4>Introduction</h4>Follicular Lymphoma (FL) results from the malignant transformation of germinal center (GC) B cells. FL B cells display recurrent and diverse genetic alterations, some of them favoring their direct interaction with their cell microenvironment, including follicular helper T cells (Tfh). Although FL-Tfh key role is well-documented, the impact of their regulatory counterpart, the follicular regulatory T cell (Tfr) compartment, is still sparse.<h4>Methods</h4>The aim of this study was to characterize FL-Tfr phenotype by cytometry, gene expression profile, FL-Tfr origin by transcriptomic analysis, and functionality by in vitro assays.<h4>Results</h4>CD4⁺CXCR5⁺CD25^hiICOS⁺ FL-Tfr displayed a regulatory program that is close to classi2024-01-01T00:00:00Z20242026-06-01T21:51:48.638Z2026-05-21T03:09:12.835ZS-EPMC111166303879944410.3389/fimmu.2024.1391404