{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["He Y"],"funding":["NCI NIH HHS"],"pagination":["e2200905"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11117022"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(15)"],"pubmed_abstract":["With the advent of bioinformatic tools in efficiently predicting neo-antigens, peptide vaccines have gained tremendous attention in cancer immunotherapy. However, the delivery of peptide vaccines remains a major challenge, primarily due to ineffective transport to lymph nodes and low immunogenicity. Here, a strategy for peptide vaccine delivery is reported by first fusing the peptide to the cytosolic domain of the stimulator of interferon genes protein (STINGΔTM), then complexing the peptide-STINGΔTM protein with STING agonist 2'3' cyclic guanosine monophosphate-adenosine monophosphate (cGAMP). The process results in the formation of self-assembled cGAMP-peptide-STINGΔTM tetramers, which enables efficient lymphatic trafficking of the peptide. Moreover, the cGAMP-STINGΔTM complex acts not o"],"journal":["Advanced healthcare materials"],"pubmed_title":["Peptide-Based Cancer Vaccine Delivery via the STINGΔTM-cGAMP Complex."],"pmcid":["PMC11117022"],"funding_grant_id":["P30 CA014051"],"pubmed_authors":["Fletcher SJ","Irvine DJ","Huang S","Belcher AM","Li J","He Y","Yang M","Berger AG","Hammond PT","Sun X","Hong C"],"additional_accession":[]},"is_claimable":false,"name":"Peptide-Based Cancer Vaccine Delivery via the STINGΔTM-cGAMP Complex.","description":"With the advent of bioinformatic tools in efficiently predicting neo-antigens, peptide vaccines have gained tremendous attention in cancer immunotherapy. However, the delivery of peptide vaccines remains a major challenge, primarily due to ineffective transport to lymph nodes and low immunogenicity. Here, a strategy for peptide vaccine delivery is reported by first fusing the peptide to the cytosolic domain of the stimulator of interferon genes protein (STINGΔTM), then complexing the peptide-STINGΔTM protein with STING agonist 2'3' cyclic guanosine monophosphate-adenosine monophosphate (cGAMP). The process results in the formation of self-assembled cGAMP-peptide-STINGΔTM tetramers, which enables efficient lymphatic trafficking of the peptide. Moreover, the cGAMP-STINGΔTM complex acts not o","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-07-15T07:55:39.294Z","creation":"2026-07-01T03:11:02.236Z"},"accession":"S-EPMC11117022","cross_references":{"pubmed":["35670244"],"doi":["10.1002/adhm.202200905"]}}