{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mano NA"],"funding":["National Institute of Food and Agriculture"],"pagination":["e594"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11117050"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(5)"],"pubmed_abstract":["The transcription factor GT2-LIKE 1 (GTL1) has been implicated in orchestrating a transcriptional network of diverse physiological, biochemical, and developmental processes. In response to water-limiting conditions, GTL1 is a negative regulator of stomatal development, but its potential rolein other water-deficit responses is unknown. We hypothesized that GTL1 regulates transcriptome changes associated with drought tolerance over leaf developmental stages. To test the hypothesis, gene expression was profiled by RNA-seq analysis in emerging and expanding leaves of wild-type and a drought-tolerant <i>gtl1-4</i> knockout mutant under well-watered and water-deficit conditions. Our comparative analysis of genotype-treatment combinations within leaf developmental age identified 459 and 1073 diff"],"journal":["Plant direct"],"pubmed_title":["Transcriptional repression of <i>GTL1</i> under water-deficit stress promotes anthocyanin biosynthesis to enhance drought tolerance."],"pmcid":["PMC11117050"],"funding_grant_id":["177845","1013618"],"pubmed_authors":["Mickelbart MV","Widhalm JR","Yoo CY","Mano NA","Shaikh MA"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptional repression of <i>GTL1</i> under water-deficit stress promotes anthocyanin biosynthesis to enhance drought tolerance.","description":"The transcription factor GT2-LIKE 1 (GTL1) has been implicated in orchestrating a transcriptional network of diverse physiological, biochemical, and developmental processes. In response to water-limiting conditions, GTL1 is a negative regulator of stomatal development, but its potential rolein other water-deficit responses is unknown. We hypothesized that GTL1 regulates transcriptome changes associated with drought tolerance over leaf developmental stages. To test the hypothesis, gene expression was profiled by RNA-seq analysis in emerging and expanding leaves of wild-type and a drought-tolerant <i>gtl1-4</i> knockout mutant under well-watered and water-deficit conditions. Our comparative analysis of genotype-treatment combinations within leaf developmental age identified 459 and 1073 diff","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-03-27T16:37:20.695Z","creation":"2025-08-27T03:10:29.942Z"},"accession":"S-EPMC11117050","cross_references":{"pubmed":["38799417"],"doi":["10.1002/pld3.594"]}}