biostudies-literatureUnknown7(5)Thilly N<h4>Importance</h4>The human papillomavirus (HPV) vaccine is safe and effective, yet vaccination coverage remains below public health objectives in many countries.<h4>Objective</h4>To examine the effectiveness of a 3-component intervention on HPV vaccination coverage among adolescents aged 11 to 14 years 2 months after the intervention ended, each component being applied alone or in combination.<h4>Design, setting, and participants</h4>A cluster randomized trial with incomplete factorial design (PrevHPV) was conducted between July 1, 2021, and April 30, 2022, in French municipalities receiving 0, 1, 2, or 3 components of the intervention. Randomization was stratified by school district and municipalities' socioeconomic level. Analyses were carried out on 11- to 14-year-old adolescents liviJAMA network opene2411938https://www.ebi.ac.uk/biostudies/studies/S-EPMC11117086biostudies-literatureEffectiveness of a School- and Primary Care-Based HPV Vaccination Intervention: The PrevHPV Cluster Randomized Trial.PMC11117086Adam IHagiu DPSimon MBonnay SZuo MBarret ASThilly NEcollan MTron ALasset CSimony MBranchereau MBocquier ARaude JLe Bel JBruel SAgrinier NBotelho-Nevers EJambon GDarlington EGagneux-Brunon APinot JGauchet AMarie Dit Asse LMichel MMueller JELevy-Bruhl DLe Duc-Banaszuk ASChyderiotis SPartouche HOudin-Doglioni DGiraudeau BBonmarin IPrevHPV Study GroupEpaulard ORossignol LKalecinski JSicsic JNekaa MVareilles GAilloud JChevreul KGilberg SBros JCastagnet CDussault JPulcini CJeanleboeuf FJuneau CFall EfalseEffectiveness of a School- and Primary Care-Based HPV Vaccination Intervention: The PrevHPV Cluster Randomized Trial.<h4>Importance</h4>The human papillomavirus (HPV) vaccine is safe and effective, yet vaccination coverage remains below public health objectives in many countries.<h4>Objective</h4>To examine the effectiveness of a 3-component intervention on HPV vaccination coverage among adolescents aged 11 to 14 years 2 months after the intervention ended, each component being applied alone or in combination.<h4>Design, setting, and participants</h4>A cluster randomized trial with incomplete factorial design (PrevHPV) was conducted between July 1, 2021, and April 30, 2022, in French municipalities receiving 0, 1, 2, or 3 components of the intervention. Randomization was stratified by school district and municipalities' socioeconomic level. Analyses were carried out on 11- to 14-year-old adolescents livi2024-01-01T00:00:00Z2024 May2026-06-03T03:58:19.742Z2026-04-24T03:09:51.185ZS-EPMC111170863878094310.1001/jamanetworkopen.2024.11938