{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kasher M"],"funding":["Wellcome Trust, Medical Research Council","European Union Horizon 2020","Biomedical Research Centre","Versus Arthritis","National Institute for Health and Care Research (NIHR) Clinical Research Network","Israel Science Foundation","Zoe Ltd.","Ariel University Research and Development Department","Wellcome Trust","Chronic Disease Research Foundation"],"pagination":["563"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11117775"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(5)"],"pubmed_abstract":["Inflammageing is a condition of perpetual low-grade inflammation induced by ageing. Inflammageing may be predicted by the C-reactive protein (CRP) or by a recently described biomarker which measures N-glycosylated side chains of the carbohydrate component of several acute-phase proteins known as GlycA. The objective of this study was to examine in depth the genetic relationships between CRP and GlycA as well as between each of them and other selected cytokines, which may shed light on the mechanisms of inflammageing. Using the Olink 96 Inflammation panel, data on inflammatory mediators for 1518 twins from the TwinsUK dataset were acquired. Summary statistics for genome-wide association studies for several cytokines as well as CRP and GlycA were collected from public sources. Extensive gene"],"journal":["Biomolecules"],"pubmed_title":["GlycA and CRP Are Genetically Correlated: Insight into the Genetic Architecture of Inflammageing."],"pmcid":["PMC11117775"],"funding_grant_id":["#RA2000000457","grant #2054/19","grant #RA2000000457","#2054/19"],"pubmed_authors":["Williams FMK","Charge Inflammation Working Group","Livshits G","Kasher M","Freidin MB"],"additional_accession":[]},"is_claimable":false,"name":"GlycA and CRP Are Genetically Correlated: Insight into the Genetic Architecture of Inflammageing.","description":"Inflammageing is a condition of perpetual low-grade inflammation induced by ageing. Inflammageing may be predicted by the C-reactive protein (CRP) or by a recently described biomarker which measures N-glycosylated side chains of the carbohydrate component of several acute-phase proteins known as GlycA. The objective of this study was to examine in depth the genetic relationships between CRP and GlycA as well as between each of them and other selected cytokines, which may shed light on the mechanisms of inflammageing. Using the Olink 96 Inflammation panel, data on inflammatory mediators for 1518 twins from the TwinsUK dataset were acquired. Summary statistics for genome-wide association studies for several cytokines as well as CRP and GlycA were collected from public sources. Extensive gene","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-04-07T16:26:01.576Z","creation":"2026-04-07T15:16:31.184Z"},"accession":"S-EPMC11117775","cross_references":{"pubmed":["38785970"],"doi":["10.3390/biom14050563"]}}