{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(5)"],"submitter":["Sabtcheva S"],"pubmed_abstract":["Carbapenemase-producing <i>Enterobacter</i> spp. <i>Serratia marcescens</i>, <i>Citrobacter freundii</i>, <i>Providencia</i> spp., and <i>Morganella morganii</i> (CP-ESCPM) are increasingly identified as causative agents of nosocomial infections but are still not under systematic genomic surveillance. In this study, using a combination of whole-genome sequencing and conjugation experiments, we sought to elucidate the genomic characteristics and transferability of resistance genes in clinical CP-ESCPM isolates from Bulgaria. Among the 36 sequenced isolates, NDM-1 (12/36), VIM-4 (11/36), VIM-86 (8/36), and OXA-48 (7/36) carbapenemases were identified; two isolates carried both NDM-1 and VIM-86. The majority of carbapenemase genes were found on self-conjugative plasmids. IncL plasmids were re"],"journal":["Antibiotics (Basel, Switzerland)"],"pagination":["455"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11117914"],"repository":["biostudies-literature"],"pubmed_title":["Genomic Characterization of Carbapenemase-Producing <i>Enterobacter hormaechei</i>, <i>Serratia marcescens</i>, <i>Citrobacter freundii</i>, <i>Providencia stuartii</i>, and <i>Morganella morganii</i> Clinical Isolates from Bulgaria."],"pmcid":["PMC11117914"],"pubmed_authors":["Stoikov I","Christova I","Lesseva M","Teneva D","Sabtcheva S","Ivanov IN","Donchev D","Dobreva E","Georgieva S"],"additional_accession":[]},"is_claimable":false,"name":"Genomic Characterization of Carbapenemase-Producing <i>Enterobacter hormaechei</i>, <i>Serratia marcescens</i>, <i>Citrobacter freundii</i>, <i>Providencia stuartii</i>, and <i>Morganella morganii</i> Clinical Isolates from Bulgaria.","description":"Carbapenemase-producing <i>Enterobacter</i> spp. <i>Serratia marcescens</i>, <i>Citrobacter freundii</i>, <i>Providencia</i> spp., and <i>Morganella morganii</i> (CP-ESCPM) are increasingly identified as causative agents of nosocomial infections but are still not under systematic genomic surveillance. In this study, using a combination of whole-genome sequencing and conjugation experiments, we sought to elucidate the genomic characteristics and transferability of resistance genes in clinical CP-ESCPM isolates from Bulgaria. Among the 36 sequenced isolates, NDM-1 (12/36), VIM-4 (11/36), VIM-86 (8/36), and OXA-48 (7/36) carbapenemases were identified; two isolates carried both NDM-1 and VIM-86. The majority of carbapenemase genes were found on self-conjugative plasmids. IncL plasmids were re","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-04-24T03:14:03.708Z","creation":"2026-04-24T03:09:38.719Z"},"accession":"S-EPMC11117914","cross_references":{"pubmed":["38786183"],"doi":["10.3390/antibiotics13050455"]}}