{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qi J"],"funding":["the National Key R&amp;D Program of China","the National Key R&D Program of China"],"pagination":["599"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11117934"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(5)"],"pubmed_abstract":["<h4>Background</h4>The discovery of traditional plants' medicinal and nutritional properties has opened up new avenues for developing pharmaceutical and dietary strategies to prevent atherosclerosis. However, the effect of the antioxidant <i>Dendrobium officinale</i> polysaccharide (DOP) on atherosclerosis is still not elucidated.<h4>Purpose</h4>This study aims to investigate the inhibitory effect and the potential mechanism of DOP on high-fat diet-induced atherosclerosis in Apolipoprotein E knockout (ApoE<sup>-/-</sup>) mice.<h4>Study design and methods</h4>The identification of DOP was measured by high-performance gel permeation chromatography (HPLC) and Fourier transform infrared spectroscopy (FTIR). We used high-fat diet (HFD)-induced atherosclerosis in ApoE<sup>-/-</sup> mice as an an"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["The Antioxidant <i>Dendrobium officinale</i> Polysaccharide Modulates Host Metabolism and Gut Microbiota to Alleviate High-Fat Diet-Induced Atherosclerosis in ApoE<sup>-/-</sup> Mice."],"pmcid":["PMC11117934"],"funding_grant_id":["2022YFF1100405"],"pubmed_authors":["Qi J","He J","Zhu Y","Luo J","Zhou S","Shi W","Wang G","Luo Y","Hua R","Wang X","Chen X","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"The Antioxidant <i>Dendrobium officinale</i> Polysaccharide Modulates Host Metabolism and Gut Microbiota to Alleviate High-Fat Diet-Induced Atherosclerosis in ApoE<sup>-/-</sup> Mice.","description":"<h4>Background</h4>The discovery of traditional plants' medicinal and nutritional properties has opened up new avenues for developing pharmaceutical and dietary strategies to prevent atherosclerosis. However, the effect of the antioxidant <i>Dendrobium officinale</i> polysaccharide (DOP) on atherosclerosis is still not elucidated.<h4>Purpose</h4>This study aims to investigate the inhibitory effect and the potential mechanism of DOP on high-fat diet-induced atherosclerosis in Apolipoprotein E knockout (ApoE<sup>-/-</sup>) mice.<h4>Study design and methods</h4>The identification of DOP was measured by high-performance gel permeation chromatography (HPLC) and Fourier transform infrared spectroscopy (FTIR). We used high-fat diet (HFD)-induced atherosclerosis in ApoE<sup>-/-</sup> mice as an an","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2025-08-27T03:08:46.291Z","creation":"2025-08-27T03:08:46.291Z"},"accession":"S-EPMC11117934","cross_references":{"pubmed":["38790704"],"doi":["10.3390/antiox13050599"]}}