biostudies-literatureQi Jthe National Key R&amp;D Program of Chinathe National Key R&D Program of China599https://www.ebi.ac.uk/biostudies/studies/S-EPMC11117934biostudies-literatureUnknown13(5)<h4>Background</h4>The discovery of traditional plants' medicinal and nutritional properties has opened up new avenues for developing pharmaceutical and dietary strategies to prevent atherosclerosis. However, the effect of the antioxidant <i>Dendrobium officinale</i> polysaccharide (DOP) on atherosclerosis is still not elucidated.<h4>Purpose</h4>This study aims to investigate the inhibitory effect and the potential mechanism of DOP on high-fat diet-induced atherosclerosis in Apolipoprotein E knockout (ApoE^-/-) mice.<h4>Study design and methods</h4>The identification of DOP was measured by high-performance gel permeation chromatography (HPLC) and Fourier transform infrared spectroscopy (FTIR). We used high-fat diet (HFD)-induced atherosclerosis in ApoE^-/- mice as an anAntioxidants (Basel, Switzerland)The Antioxidant <i>Dendrobium officinale</i> Polysaccharide Modulates Host Metabolism and Gut Microbiota to Alleviate High-Fat Diet-Induced Atherosclerosis in ApoE^-/- Mice.PMC111179342022YFF1100405Qi JHe JZhu YLuo JZhou SShi WWang GLuo YHua RWang XChen XWang ZfalseThe Antioxidant <i>Dendrobium officinale</i> Polysaccharide Modulates Host Metabolism and Gut Microbiota to Alleviate High-Fat Diet-Induced Atherosclerosis in ApoE^-/- Mice.<h4>Background</h4>The discovery of traditional plants' medicinal and nutritional properties has opened up new avenues for developing pharmaceutical and dietary strategies to prevent atherosclerosis. However, the effect of the antioxidant <i>Dendrobium officinale</i> polysaccharide (DOP) on atherosclerosis is still not elucidated.<h4>Purpose</h4>This study aims to investigate the inhibitory effect and the potential mechanism of DOP on high-fat diet-induced atherosclerosis in Apolipoprotein E knockout (ApoE^-/-) mice.<h4>Study design and methods</h4>The identification of DOP was measured by high-performance gel permeation chromatography (HPLC) and Fourier transform infrared spectroscopy (FTIR). We used high-fat diet (HFD)-induced atherosclerosis in ApoE^-/- mice as an an2024-01-01T00:00:00Z2024 May2025-08-27T03:08:46.291Z2025-08-27T03:08:46.291ZS-EPMC111179343879070410.3390/antiox13050599