biostudies-literatureBillig SAbiomed (Germany)RWTH Aachen University456https://www.ebi.ac.uk/biostudies/studies/S-EPMC11118512biostudies-literatureUnknown11(5)The survival rate of cardiac arrest (CA) can be improved by utilizing percutaneous left ventricular assist devices (pLVADs) instead of conventional chest compressions. However, existing pLVADs require complex fluoroscopy-guided placement along a guidewire and suffer from limited blood flow due to their cross-sectional area. The recently developed self-expandable Impella CP (ECP) pLVAD addresses these limitations by enabling guidewire-free placement and increasing the pump cross-sectional area. This study evaluates the feasibility of resuscitation using the Impella ECP in a swine CA model. Eleven anesthetized pigs (73.8 ± 1.7 kg) underwent electrically induced CA, were left untreated for 5 min and then received pLVAD insertion and activation. Vasopressors were administered and defibrillatioBioengineering (Basel, Switzerland)The Self-Expandable Impella CP (ECP) as a Mechanical Resuscitation Device.PMC11118512unrestricted educational research grantClinician Scientist Program for Sebastian BilligBillig SYelenski SBennek-Schoepping EZayat RNix CDerwall MHochhausen NfalseThe Self-Expandable Impella CP (ECP) as a Mechanical Resuscitation Device.The survival rate of cardiac arrest (CA) can be improved by utilizing percutaneous left ventricular assist devices (pLVADs) instead of conventional chest compressions. However, existing pLVADs require complex fluoroscopy-guided placement along a guidewire and suffer from limited blood flow due to their cross-sectional area. The recently developed self-expandable Impella CP (ECP) pLVAD addresses these limitations by enabling guidewire-free placement and increasing the pump cross-sectional area. This study evaluates the feasibility of resuscitation using the Impella ECP in a swine CA model. Eleven anesthetized pigs (73.8 ± 1.7 kg) underwent electrically induced CA, were left untreated for 5 min and then received pLVAD insertion and activation. Vasopressors were administered and defibrillatio2024-01-01T00:00:00Z2024 May2026-07-14T10:22:20.53Z2026-06-29T03:09:37.666ZS-EPMC111185123879032310.3390/bioengineering11050456