biostudies-literatureUnknownMedina NDNINDS NIH HHSNeuronal intrinsic excitability is a mechanism implicated in learning and memory that is distinct from synaptic plasticity. Prior work in songbirds established that intrinsic properties (IPs) of premotor basal-ganglia-projecting neurons (HVC_X) relate to learned song. Here we find that temporal song structure is related to specific HVC_X IPs: HVC_X from birds who sang longer songs including longer invariant vocalizations (harmonic stacks) had IPs that reflected increased post-inhibitory rebound. This suggests a rebound excitation mechanism underlying the ability of HVC_X neurons to integrate over long periods of time throughout the song and represent sequence information. To explore this, we constructed a network model of realistic neurons showing hobioRxiv : the preprint server for biology2024.05.18.594825https://www.ebi.ac.uk/biostudies/studies/S-EPMC11118566biostudies-literatureBursts from the past: Intrinsic properties link a network model to zebra finch song.PMC11118566UF1 NS115821Medina NDMargoliash DfalseBursts from the past: Intrinsic properties link a network model to zebra finch song.Neuronal intrinsic excitability is a mechanism implicated in learning and memory that is distinct from synaptic plasticity. Prior work in songbirds established that intrinsic properties (IPs) of premotor basal-ganglia-projecting neurons (HVC_X) relate to learned song. Here we find that temporal song structure is related to specific HVC_X IPs: HVC_X from birds who sang longer songs including longer invariant vocalizations (harmonic stacks) had IPs that reflected increased post-inhibitory rebound. This suggests a rebound excitation mechanism underlying the ability of HVC_X neurons to integrate over long periods of time throughout the song and represent sequence information. To explore this, we constructed a network model of realistic neurons showing ho2025-01-01T00:00:00Z2025 Aug2026-07-06T03:11:34.4Z2026-07-06T03:08:35.477ZS-EPMC111185663879833210.1101/2024.05.18.594825