{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mara P"],"funding":["National Science Foundation (NSF)","National Science Foundation"],"pagination":["929"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11123730"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(5)"],"pubmed_abstract":["Plasmids are mobile genetic elements known to carry secondary metabolic genes that affect the fitness and survival of microbes in the environment. Well-studied cases of plasmid-encoded secondary metabolic genes in marine habitats include toxin/antitoxin and antibiotic biosynthesis/resistance genes. Here, we examine metagenome-assembled genomes (MAGs) from the permanently-stratified water column of the Cariaco Basin for integrated plasmids that encode biosynthetic gene clusters of secondary metabolites (smBGCs). We identify 16 plasmid-borne smBGCs in MAGs associated primarily with Planctomycetota and Pseudomonadota that encode terpene-synthesizing genes, and genes for production of ribosomal and non-ribosomal peptides. These identified genes encode for secondary metabolites that are mainly "],"journal":["Microorganisms"],"pubmed_title":["Plasmid-Borne Biosynthetic Gene Clusters within a Permanently Stratified Marine Water Column."],"pmcid":["PMC11123730"],"funding_grant_id":["OCE-1259110","OCE-1336082 To Virginia Edgcomb","OCE-1335436","OCE-1335436 and OCE-1259110 to Gordon T Taylor","OCE-1336082"],"pubmed_authors":["Mara P","Pachiadaki MG","Suter E","Geller-McGrath D","Taylor GT","Edgcomb VP"],"additional_accession":[]},"is_claimable":false,"name":"Plasmid-Borne Biosynthetic Gene Clusters within a Permanently Stratified Marine Water Column.","description":"Plasmids are mobile genetic elements known to carry secondary metabolic genes that affect the fitness and survival of microbes in the environment. Well-studied cases of plasmid-encoded secondary metabolic genes in marine habitats include toxin/antitoxin and antibiotic biosynthesis/resistance genes. Here, we examine metagenome-assembled genomes (MAGs) from the permanently-stratified water column of the Cariaco Basin for integrated plasmids that encode biosynthetic gene clusters of secondary metabolites (smBGCs). We identify 16 plasmid-borne smBGCs in MAGs associated primarily with Planctomycetota and Pseudomonadota that encode terpene-synthesizing genes, and genes for production of ribosomal and non-ribosomal peptides. These identified genes encode for secondary metabolites that are mainly ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2026-06-28T03:09:33.825Z","creation":"2026-06-28T03:05:14.875Z"},"accession":"S-EPMC11123730","cross_references":{"pubmed":["38792759"],"doi":["10.3390/microorganisms12050929"]}}