{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Curvino EJ"],"funding":["NIBIB NIH HHS","NIAID NIH HHS","National Science Foundation (NSF)"],"pagination":["628-649"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11128482"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(5)"],"pubmed_abstract":["Inflammatory bowel disease lacks a long-lasting and broadly effective therapy. Here, by taking advantage of the anti-infection and anti-inflammatory properties of natural antibodies against the small-molecule epitope phosphorylcholine (PC), we show in multiple mouse models of colitis that immunization of the animals with self-assembling supramolecular peptide nanofibres bearing PC epitopes induced sustained levels of anti-PC antibodies that were both protective and therapeutic. The strength and type of immune responses elicited by the nanofibres could be controlled through the relative valency of PC epitopes and exogenous T-cell epitopes on the nanofibres and via the addition of the adjuvant CpG. The nanomaterial-assisted induction of the production of therapeutic antibodies may represent "],"journal":["Nature biomedical engineering"],"pubmed_title":["Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres."],"pmcid":["PMC11128482"],"funding_grant_id":["R01 EB009701","R01 AI172151","DGE-1644868"],"pubmed_authors":["Collier JH","Curvino EJ","Segura T","Woodruff ME","Freire Haddad H","Votaw NL","Hale LP","Anderson AR","Roe EF"],"additional_accession":[]},"is_claimable":false,"name":"Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres.","description":"Inflammatory bowel disease lacks a long-lasting and broadly effective therapy. Here, by taking advantage of the anti-infection and anti-inflammatory properties of natural antibodies against the small-molecule epitope phosphorylcholine (PC), we show in multiple mouse models of colitis that immunization of the animals with self-assembling supramolecular peptide nanofibres bearing PC epitopes induced sustained levels of anti-PC antibodies that were both protective and therapeutic. The strength and type of immune responses elicited by the nanofibres could be controlled through the relative valency of PC epitopes and exogenous T-cell epitopes on the nanofibres and via the addition of the adjuvant CpG. The nanomaterial-assisted induction of the production of therapeutic antibodies may represent ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 May","modification":"2025-04-04T13:19:33.082Z","creation":"2025-04-04T13:19:33.082Z"},"accession":"S-EPMC11128482","cross_references":{"pubmed":["38012308"],"doi":["10.1038/s41551-023-01139-6"]}}